研究主题:Diabetes, Glucotoxicity, Oxidative Stress
详细题名日期
查看Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays.20140408
查看Group VIA Phospholipase A2 Mitigates Palmitate-Induced Beta Cell Mitochondrial Injury and Apoptosis.20140408
查看Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor alpha20140408
查看Proteasome dysfunction mediates high glucose-induced apoptosis in rodent Beta cells and human islets.20140408
查看Thioredoxin-Interacting Protein Stimulates its Own Expression via a Positive Feedback Loop.20140408
查看The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.20140408
查看Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through MIR-124A and FOXA2.20140408
查看The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.20140408
查看Xuezhikang attenuated the functional and morphological impairment of pancreatic islets in diabetic mice via the inhibition of oxidative stress.20140408
查看Progesterone induces apoptosis of insulin-secreting cells: insights into the molecular mechanism.20140408
查看Calcium efflux from the endoplasmic reticulum leads to beta-cell death.20140408
查看The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in betaTC6 cells.20140408
查看Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress response.20140408
查看High-Fat-Fed Obese Glutathione Peroxidase 1-Deficient Mice Exhibit Defective Insulin Secretion but Protection from Hepatic Steatosis and Liver Damage.20140408
查看Cocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stress.20140408
查看Liraglutide protects Rin-m5f beta cells by reducing procoagulant tissue factor activity and apoptosis prompted by microparticles under conditions mimicking Instant Blood Mediated Inflammatory Reaction.20140317
查看Anti-diabetic properties of a non-conventional radical scavenger, as compared to pioglitazone and exendin-4, in streptozotocin-nicotinamide diabetic mice.20140317
查看Iron: the hard player in diabetes pathophysiology.20140317
查看Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes.20140317
查看Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic beta-cell function in diabetes.20140317
查看Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice.20140317
查看The Islet Estrogen Receptor-alpha Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes.20140317
查看Chronic High Glucose and Pyruvate Levels Differentially Affect Mitochondrial Bioenergetics and Fuel-stimulated Insulin Secretion from Clonal INS-1 832/13 Cells.20140317
查看High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 beta-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit.20140317
查看Nrf2 protects pancreatic beta-cells from oxidative and nitrosative stress in diabetic model mice.20140317
查看O-GlcNAcylation of FoxO1 in pancreatic beta cells promotes Akt inhibition through an IGFBP1-mediated autocrine mechanism.20140317
查看Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes.20140217
查看Serum GGT activity and hsCRP level in patients with type 2 diabetes mellitus with good and poor glycemic control: An evidence linking oxidative stress, inflammation and glycemic control.20140217
查看Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.20140217
查看beta-cell dedifferentiation in diabetes is important, but what is it?20140217
查看At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death.20140217
查看Elevated levels of branched chain amino acids have little effect on pancreatic islet cells but L-arginine impairs function through activation of the endoplasmic reticulum stress response.20140217
查看Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells.20140217
查看Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in beta Cells.20140217
查看Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes.20140217
查看Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity.20140217
查看Genetic Disruption of SOD1 Gene Causes Glucose Intolerance and Impairs beta-Cell Function.20140217
查看Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway.20140217
查看Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes.20140217
查看Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice.20140217
查看The Islet Estrogen Receptor-alpha Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes.20140217
查看Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways.20140217
查看JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis.20140217
查看Deregulation of Pancreas-Specific Oxidoreductin ERO1beta in the Pathogenesis of Diabetes Mellitus.20140217
查看Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress.20140217
查看Treatment of hyperglycemia in newly diagnosed diabetic patients is associated with a reduction in oxidative stress and improvement in beta-cell function.20140217
查看Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis through Nrf2 mechanism.20140217
查看Death and dysfunction of transplanted beta-cells: lessons learned from type 2 diabetes?20140217
查看Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in beta Cells.20140217
查看Advanced glycation end products (AGE) and diabetes: cause, effect, or both?20140217
查看Glucose-stimulated oxidative stress in mononuclear cells is related to pancreatic beta-cell dysfunction in polycystic ovary syndrome.20140217
查看Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic beta-cell death.20140217
查看Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells.20140217
查看Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4.20140217
查看Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes.20140102
查看Serum GGT activity and hsCRP level in patients with type 2 diabetes mellitus with good and poor glycemic control: An evidence linking oxidative stress, inflammation and glycemic control.20140102
查看Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.20140102
查看beta-cell dedifferentiation in diabetes is important, but what is it?20140102
查看At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death.20140102
查看Elevated levels of branched chain amino acids have little effect on pancreatic islet cells but L-arginine impairs function through activation of the endoplasmic reticulum stress response.20140102
查看Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells.20140102
查看Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in beta Cells.20140102
查看Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes.20140102
查看Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity.20140102
查看Genetic Disruption of SOD1 Gene Causes Glucose Intolerance and Impairs beta-Cell Function.20140102
查看Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway.20140102
查看High Glucose Exposure Promotes Activation of Protein Phosphatase 2A in Rodent Islets and INS-1 832/13 beta-Cells by Increasing the Posttranslational Carboxylmethylation of Its Catalytic Subunit.20131203
查看High fat fed obese Gpx1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage.20131203
查看Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes.20131203
查看A crosstalk between p21 and UPR-induced transcription factor C/EBP homologous protein (CHOP) linked to type 2 diabetes.20131203
查看Caffeic acid, Naringenin and Quercetin enhance glucose stimulated insulin secretion and glucose sensitivity in INS-1E cells.20131203
查看Glucose-stimulated oxidative stress in mononuclear cells is related to pancreatic beta-cell dysfunction in polycystic ovary syndrome.20131203
查看Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.20131203
查看Nrf2 Protects Pancreatic beta-Cells from Oxidative and Nitrosative Stress in Diabetic Model Mice.20131203
查看Oral intralipid emulsion use: a novel therapeutic approach to pancreatic beta-cell injury caused by malathion toxicity in rats.20131203
查看Antioxidant N-acetylcysteine protects pancreatic beta-cells against aldosterone-induced oxidative stress and apoptosis in female db/db mice and insulin-producing MIN6 cells.20131203
查看gamma-Aminobutyric Acid Regulates Both the Survival and Replication of Human beta-Cells.20131203
查看Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic beta-cells: protection by nifedipine.20131203
查看Testosterone protects against glucotoxicity-induced apoptosis of pancreatic beta-cells (INS-1) and male mouse pancreatic islets.20131203
查看O-GlcNAcylation of FoxO1 in pancreatic beta cells promotes Akt inhibition through an IGFBP1-mediated autocrine mechanism.20131104
查看Melatonin prevents pancreatic beta-cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress.20131104
查看Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic beta-cell death.20131104
查看Do plants mediate their anti-diabetic effects through anti-oxidant and anti-apoptotic actions? an in vitro assay of 3 Indian medicinal plants.20131104
查看Chronic high glucose induced INS-1beta cell mitochondrial dysfunction: A comparative mitochondrial proteome with SILAC.20131104
查看Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves beta-Cell Mass and Function in ZDF Rats.20131104
查看Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells.20131002
查看Small-molecule inhibition of inflammatory beta-cell death.20131002
查看Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway.20131002
查看Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets.20131002
查看Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived beta-cells.20131002
查看Clinical evidence for the earlier initiation of insulin therapy in type 2 diabetes.20131002
查看Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic beta-cells: Protection by nifedipine.20130902
查看Testosterone protects against glucotoxicity induced apoptosis of pancreatic beta-cells (INS-1) and male mouse pancreatic islets.20130902
查看Chronic high glucose-induced INS-1beta cell mitochondrial dysfunction: a comparative mitochondrial proteome with SILAC.20130902
查看Alternanthera paronychioides protects pancreatic beta-cells from glucotoxicity by its antioxidant, antiapoptotic and insulin secretagogue actions.20130902
查看Influence of chronic hyperglycemia on the loss of the UPR in transplanted islets.20130830
查看Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived beta-cells.20130830
查看Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves beta-cell mass and function in ZDF rats.20130830
查看Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves beta-cell mass and function in ZDF rats.20130702
查看Clinical Evidence for the Earlier Initiation of Insulin Therapy in Type 2 Diabetes.20130702
查看Pathophysiology of prediabetes and treatment implications for the prevention of type 2 diabetes mellitus.20130702
查看Antiapoptotic effects of cerium oxide and yttrium oxide nanoparticles in isolated rat pancreatic islets.20130606
查看Activation of apocynin-sensitive NADPH oxidase (Nox2) activity in INS-1 832/13 cells under glucotoxic conditions.20130606
查看Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats.20130606
查看Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions.20130606
查看Glucagon-like Peptide-1 triggers protective pathways in pancreatic Beta-cells exposed to glycated serum.20130430
查看Is There U Turn From Insulin Back to Pills in Diabetes?20130430
查看A prescribed Chinese herbal medicine improves glucose profile and ameliorates oxidative stress in Goto-Kakisaki rats fed with high fat diet.20130430
查看NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction.20130430
查看Islet beta cell mass in diabetes and how it relates to function, birth, and death.20130430
查看miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models.20130430
查看Liraglutide prevents high glucose level induced insulinoma cells apoptosis by targeting autophagy.20130330
查看Iron and diabetes risk.20130330
查看Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells.20130330
查看Metabolomic analysis of pancreatic beta cells following exposure to high glucose.20130330
查看Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding.20130228
查看Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.20130228
查看Lipotoxicity impairs incretin signalling.20130228
查看Involvement of the Ca2+-responsive transactivator in high glucose-induced beta-cell apoptosis.20130228
查看Localization and regulation of pancreatic selenoprotein P.20130228
查看Glucagon-like Peptide-1 triggers protective pathways in pancreatic Beta-cells exposed to glycated serum.20130131
查看A prescribed Chinese herbal medicine improves glucose profile and ameliorates oxidative stress in Goto-Kakisaki rats fed with high fat diet.20130131
查看NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction.20130131
查看Alternanthera paronychioides protects pancreatic beta-cells from glucotoxicity by its antioxidant, antiapoptotic and insulin secretagogue actions.20130131
查看Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding.20130131
查看Islet beta cell mass in diabetes and how it relates to function, birth, and death.20130131
查看miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models.20130131
查看Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells.20130131
查看The impact of oxidative stress on islet transplantation and monitoring the graft survival by non-invasive imaging.20130131
查看Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone.20130131
查看RIP140 mediates hyperglycemia-induced glucotoxicity in beta-cells via the activation of JNK and ERK1/2 signaling pathways.20130131
查看Involvement of the Ca2+-responsive transactivator in high glucose-induced beta-cell apoptosis.20130131
查看Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.20130131
查看Gene characterisation, isoforms and recombinant expression of carcinin, an antibacterial protein from the shore crab, Carcinus maenas061130
查看Isolation and characterization of a novel thermostable non-specific lipid transfer protein-like antimicrobial protein from motherwort (Leonurus japonicus Houtt) seeds061130
查看Identification and expression of gene transcripts generated during an anti-parasitic response in Biomphalaria glabrata061130
查看Salivary histatins in human deep posterior lingual glands (of von Ebner)061130
查看The antifungal properties of a 2S albumin-homologous protein from passion fruit seeds involve plasma membrane permeabilization and ultrastructural alterations in yeast cells061130
查看No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block061130
查看Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening061130
查看Cholinergic regulation of epithelial ion transport in the mammalian intestine061130
查看Microbial translocation is a cause of systemic immune activation in chronic HIV infection061130
查看Group B Streptococcus: global incidence and vaccine development061130
查看Identification of substrates of the Mycobacterium tuberculosis proteasome061130
查看The contact system?—a novel branch of innate immunity generating antibacterial peptides061130
查看The isoprenoid pathway in the ectomycorrhizal fungus Tuber borchii Vittad.: cloning and characterisation of the tbhmgr, tbfpps and tbsqs genes.060930
查看Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA.060930
查看IDENTIFICATION OF A HUMAN ORTHOLOGUE OF THE MOUSE Dcpp GENE LOCUS, ENCODING A NOVEL MEMBER OF THE CSP-1/Dcpp SALIVARY PROTEIN FAMILY.060930
查看SIGNAL TRANSDUCTION AND NUCLEAR RESPONSES IN STAPHYLOCOCCUS AUREUS-INDUCED EXPRESSION OF HUMAN {beta}-DEFENSIN-3 IN SKIN KERATINOCYTES.060930
查看Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide.060930
查看Proteome Analysis of Vernix Caseosa.060930
查看Identification of RNase 8 as a Novel Human Antimicrobial Protein.060930
查看Prior antibacterial Peptide-mediated inhibition of protein folding in bacteria mutes resistance enzymes.060930
查看Biological Activities and 3D QSAR Studies of a Series of Delisea pulchra (cf. fimbriata) Derived Natural Products.060930
查看Symbiotic bacteria direct expression of an intestinal bactericidal lectin.060930
查看The peptidoglycan recognition proteins (PGRPs).060930
查看Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration.060930
查看Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells.060930
查看Whole cell strategies based on lux genes for high throughput applications toward new antimicrobials.060930
查看Drug Insight: adjunctive therapies in adults with bacterial meningitis 060930
查看The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.060930
查看Structure of the catalytic domain of the hepatitis C virus NS2-3 protease.060930
查看Crystal Structure of the Monomeric Porin OmpG.060930
查看Platensimycin is a selective FabF inhibitor with potent antibiotic properties.060930
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