研究主题:Diabetes, ER stress, IAPP, UPR
详细题名日期
查看High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.20140408
查看Lipotoxic endoplasmic reticulum stress, beta cell failure, and type 2 diabetes mellitus.20140408
查看The Ability of Insulin to Inhibit Amyloid Formation by ProIAPP Processing Intermediates Is Significantly Reduced in the Presence of Sulfated Glycosaminoglycans.20140408
查看Group VIA Phospholipase A2 Mitigates Palmitate-Induced Beta Cell Mitochondrial Injury and Apoptosis.20140408
查看Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor alpha20140408
查看Proteasome dysfunction mediates high glucose-induced apoptosis in rodent Beta cells and human islets.20140408
查看Elevation of NR4A3 Expression and Its Possible Role in Modulating Insulin Expression in the Pancreatic Beta Cell.20140408
查看Inhibition of palmitate-induced GADD34 expression augments apoptosis in mouse insulinoma cells (MIN6).20140408
查看Islet Amyloid Polypeptide is not a Target Antigen for CD8+ T-Cells in Type 2 Diabetes.20140408
查看Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through MIR-124A and FOXA2.20140408
查看The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.20140408
查看Progesterone induces apoptosis of insulin-secreting cells: insights into the molecular mechanism.20140408
查看Multiparameter Screening Reveals a Role for Na(+) Channels in Cytokine-Induced beta-Cell Death.20140408
查看Calcium efflux from the endoplasmic reticulum leads to beta-cell death.20140408
查看Interaction of Nck1 and PERK phosphorylated at Y561 negatively modulates PERK activity and PERK regulation of pancreatic beta-cell proinsulin content.20140408
查看Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?20140408
查看Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress response.20140408
查看Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells.20140408
查看beta-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.20140408
查看Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes.20140317
查看Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic beta-cell function in diabetes.20140317
查看The Islet Estrogen Receptor-alpha Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes.20140317
查看Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects.20140317
查看High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 beta-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit.20140317
查看Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes.20140217
查看The Islet Estrogen Receptor-alpha Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes.20140217
查看JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis.20140217
查看Deregulation of Pancreas-Specific Oxidoreductin ERO1beta in the Pathogenesis of Diabetes Mellitus.20140217
查看The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets.20140217
查看Multi-parameter screening reveals a role for Na channels in cytokine-induced beta-cell death.20140217
查看The protective effects and genetic pathways of thorn grape seeds oil against high glucose-induced apoptosis in pancreatic beta-cells.20140217
查看p85alpha deficiency protects beta-cells from endoplasmic reticulum stress-induced apoptosis.20140217
查看Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets.20140217
查看Death and dysfunction of transplanted beta-cells: lessons learned from type 2 diabetes?20140217
查看Insulin, islet amyloid polypeptide and C-peptide interactions evaluated by mass spectrometric analysis.20140217
查看GATA factors promote ER integrity and beta-cell survival and contribute to type 1 diabetes risk.20140217
查看Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic beta-cell death.20140217
查看RNA-sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.20140102
查看Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets.20140102
查看Interaction of Nck1 and PERK phosphorylated at Y561 negatively modulates PERK activity and PERK regulation of Pancreatic beta-cell Proinsulin Content.20140102
查看Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?20140102
查看Mitogen-activated protein kinases and protein phosphatase 5 mediate glucocorticoid-induced cytotoxicity in pancreatic islets and beta-cells.20140102
查看4-Phenylbutyric acid attenuates endoplasmic reticulum stress-mediated pancreatic beta-cell apoptosis in rats with streptozotocin-induced diabetes.20140102
查看Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects.20140102
查看Elevated levels of branched chain amino acids have little effect on pancreatic islet cells but L-arginine impairs function through activation of the endoplasmic reticulum stress response.20140102
查看Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells.20140102
查看Molecular simulations indicate marked differences in the structure of amylin mutants, correlated with known aggregation propensity.20140102
查看Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes.20140102
查看Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity.20140102
查看Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway.20140102
查看HDLs protect the MIN6 insulinoma cell line against tunicamycin-induced apoptosis without inhibiting ER stress and without restoring ER functionality.20140102
查看In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated beta-cell dysfunction during the progression of type-2 diabetes.20140102
查看GATA factors promote ER integrity, beta-cell survival, and contribute to type 1 diabetes risk.20131203
查看High Glucose Exposure Promotes Activation of Protein Phosphatase 2A in Rodent Islets and INS-1 832/13 beta-Cells by Increasing the Posttranslational Carboxylmethylation of Its Catalytic Subunit.20131203
查看Molecular Simulations Indicate Marked Differences in the Structure of Amylin Mutants, Correlated with Known Aggregation Propensity.20131203
查看A crosstalk between p21 and UPR-induced transcription factor C/EBP homologous protein (CHOP) linked to type 2 diabetes.20131203
查看Beta cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.20131203
查看Restoration of the Unfolded Protein Response in Pancreatic beta Cells Protects Mice Against Type 1 Diabetes.20131203
查看Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1beta production and beta cell dysfunction.20131203
查看Oleate rescues INS-1E beta-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response.20131203
查看Insulin Secretion and Ca2+ Dynamics in beta-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin.20131203
查看Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS.20131203
查看Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic beta-cells: protection by nifedipine.20131203
查看Testosterone protects against glucotoxicity-induced apoptosis of pancreatic beta-cells (INS-1) and male mouse pancreatic islets.20131203
查看Autosomal dominant diabetes arising from a wolfram syndrome 1 mutation.20131203
查看Melatonin prevents pancreatic beta-cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress.20131104
查看ER stress in rodent islets of Langerhans is concomitant with obesity and beta-cell compensation but not with beta-cell dysfunction and diabetes.20131104
查看Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic beta-cell death.20131104
查看Insulin secretion and Ca2+ dynamics in beta-cells are regulated by PERK eIF2alpha kinase in concert with calcineurin.20131104
查看Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity.20131104
查看Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.20131104
查看Endoplasmic Reticulum Oxidoreductin-1alpha (Ero1alpha) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress.20131104
查看Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms.20131104
查看AMPK Regulates ER Morphology and Function in Stressed Pancreatic beta-Cells via Phosphorylation of DRP1.20131104
查看The role of FOXO1 in beta-cell failure and type 2 diabetes mellitus.20131104
查看Glucokinase Activation Ameliorates ER Stress-Induced Apoptosis in Pancreatic beta-Cells.20131104
查看C-Peptide: A Molecule Balancing Insulin States in Secretion and Diabetes-associated Depository Conditions.20131104
查看Differential Protective Effects of Exenatide, an Agonist of GLP-1 Receptor and Piragliatin, a Glucokinase Activator in Beta Cell Response to Streptozotocin-Induced and Endoplasmic Reticulum Stresses.20131002
查看Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.20131002
查看Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS.20131002
查看Lost in translation: endoplasmic reticulum stress and the decline of beta-cell health in diabetes mellitus.20131002
查看Role of pancreatic beta-cell death and inflammation in diabetes.20131002
查看Endoplasmic Reticulum Oxidoreductin-1alpha (Ero1alpha) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-Induced ER Stress.20131002
查看Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway.20131002
查看Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic beta-Cells.20131002
查看Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 beta-cell line.20131002
查看Multi-parameter single-cell kinetic analysis reveals multiple modes of cell death in primary pancreatic beta-cells.20131002
查看Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets.20131002
查看Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived beta-cells.20131002
查看Structural Similarities and Differences between Amyloidogenic and Non-Amyloidogenic Islet Amyloid Polypeptide (IAPP) Sequences and Implications for the Dual Physiological and Pathological Activities of These Peptides.20130902
查看Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms.20130902
查看Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic beta-cells: Protection by nifedipine.20130902
查看HDLs protect the MIN6 insulinoma cell line against tunicamycin-induced apoptosis without inhibiting ER stress and without restoring ER functionality.20130902
查看Cellular responses of novel human pancreatic beta-cell line, 1.1B4 to hyperglycemia.20130902
查看AMPK regulates ER morphology and function in stressed pancreatic beta-cells via phosphorylation of DRP1.20130902
查看Characterization of FKGK18 as Inhibitor of Group VIA Ca(2+)-Independent Phospholipase A2 (iPLA2beta): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes.20130902
查看Testosterone protects against glucotoxicity induced apoptosis of pancreatic beta-cells (INS-1) and male mouse pancreatic islets.20130902
查看The role of FOXO1 in beta-cell failure and type 2 diabetes mellitus.20130902
查看In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated beta-cell dysfunction during the progression of type-2 diabetes.20130902
查看The Antipsychotic Olanzapine Induces Apoptosis in Insulin-secreting Pancreatic beta Cells by Blocking PERK-mediated Translational Attenuation.20130902
查看Changing faces, unmasking the beta-cell: post-translational modification of antigens in type 1 diabetes.20130902
查看Deletion of retinoic acid receptor beta (RARbeta) impairs pancreatic endocrine differentiation.20130902
查看One year of sitagliptin treatment protects against islet amyloid-associated beta-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice.20130902
查看Glycated albumin causes pancreatic beta-cells dysfunction through autophagy dysfunction.20130902
查看Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic beta-Cells.20130902
查看Autosomal Dominant Diabetes Arising from a Wolfram Syndrome 1 Mutation.20130830
查看Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic beta-cells.20130830
查看Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress.20130830
查看Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line.20130830
查看Multi-parameter, single-cell, kinetic analysis reveals multiple modes of cell death in primary pancreatic beta-cells.20130830
查看Role of ceramide in diabetes mellitus: evidence and mechanisms.20130830
查看Influence of chronic hyperglycemia on the loss of the UPR in transplanted islets.20130830
查看Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1beta-induced apoptosis via Bim/A1 imbalance.20130830
查看Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived beta-cells.20130830
查看Crude extract of Ceriporia lacerata has a protective effect on dexamethasone-induced cytotoxicity in INS-1 cells via the modulation of PI3K/PKB activity.20130830
查看A novel mechanism regulating insulin secretion involving Herpud1 in mice.20130830
查看X-box binding protein 1 is essential for insulin regulation of pancreatic alpha-cell function.20130830
查看Effects of lipotoxicity on a novel insulin-secreting human pancreatic beta-cell line, 1.1B4.20130830
查看Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic beta cells.20130702
查看C-Peptide: A Molecule Balancing Insulin States in Secretion and Diabetes-associated Depository Conditions.20130702
查看Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations.20130702
查看Deletion of retinoic acid receptor beta (RARbeta) impairs pancreatic endocrine differentiation.20130702
查看One year of sitagliptin treatment protects against islet amyloid-associated beta-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice.20130702
查看A Self-defeating Anabolic Program Leads to beta-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux.20130702
查看Cosolvent effects on the fibrillation reaction of human IAPP.20130702
查看Novel autoantigens in type 1 diabetes.20130606
查看Natural food science based novel approach toward prevention and treatment of obesity and type 2 diabetes: Recent studies on brown rice and gamma-oryzanol.20130606
查看Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions.20130606
查看Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic beta-Cells.20130606
查看A Self-Defeating Anabolic Program Leads to beta cell apoptosis in ER Stress-Induced Diabetes via Regulation of Amino Acid Flux.20130606
查看The role of the unfolded protein response in diabetes mellitus.20130606
查看Inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salen derivatives.20130606
查看GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice.20130606
查看Crude extract of Ceriporia lacerata has a protective effect on dexamethasone-induced cytotoxicity in INS-1 cells via the modulation of PI3K/PKB activity.20130430
查看Gene expression analysis of human islets in a subject at onset of type 1 diabetes.20130430
查看A novel mechanism regulating insulin secretion involving Herpud1 in mice.20130430
查看Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide.20130430
查看Improvement of ER stress-induced diabetes by stimulating autophagy.20130430
查看Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.20130430
查看Mechanisms of islet amyloidosis toxicity in type 2 diabetes.20130430
查看Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.20130430
查看The role of the unfolded protein response in diabetes mellitus.20130330
查看Inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salen derivatives.20130330
查看Free fatty acid induces endoplasmic reticulum stress and apoptosis of beta-cells by Ca2+/calpain-2 pathways.20130330
查看Adsorption and Orientation of Human Islet Amyloid Polypeptide (hIAPP) Monomer at Anionic Lipid Bilayers: Implications for Membrane-Mediated Aggregation.20130330
查看Cosolvent effects on the fibrillation reaction of human IAPP.20130330
查看X-box binding protein 1 is essential for insulin regulation of pancreatic alpha cell function.20130330
查看GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice.20130330
查看Differential responses of pancreatic beta-cells to ROS and RNS.20130330
查看Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats.20130330
查看The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation.20130330
查看Exendin-4 inhibits glucolipotoxic ER stress in pancreatic beta cells via regulation of SREBP1c and C/EBPbeta transcription factors.20130330
查看Elimination of endoplasmic reticulum stress and cardiovascular, type 2 diabetic, and other metabolic diseases.20130330
查看Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding.20130228
查看Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.20130228
查看Lipotoxicity impairs incretin signalling.20130228
查看Involvement of the Ca2+-responsive transactivator in high glucose-induced beta-cell apoptosis.20130228
查看Localization and regulation of pancreatic selenoprotein P.20130228
查看Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations.20130131
查看Novel autoantigens in type 1 diabetes.20130131
查看Free fatty acid induces endoplasmic reticulum stress and apoptosis of beta-cells by Ca2+/calpain-2 pathways.20130131
查看Genetic modulation of islet beta-cell iPLA(2)beta expression provides evidence for its impact on beta-cell apoptosis and autophagy.20130131
查看Taurine supplementation restores insulin secretion and reduces ER stress markers in protein-malnourished mice.20130131
查看Bisphenol A accelerates toxic amyloid formation of human islet amyloid polypeptide: a possible link between bisphenol A exposure and type 2 diabetes.20130131
查看Role of autophagy in the progression from obesity to diabetes and in the control of energy balance.20130131
查看Mechanisms of islet amyloidosis toxicity in type 2 diabetes.20130131
查看Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.20130131
查看Differential responses of pancreatic beta-cells to ROS and RNS.20130131
查看Na(+)/Ca (2+) exchange and the plasma membrane Ca(2+)-ATPase in beta-cell function and diabetes.20130131
查看Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced beta-cell death.20130131
查看Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction.20130131
查看Involvement of the Ca2+-responsive transactivator in high glucose-induced beta-cell apoptosis.20130131
查看Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.20130131
查看Tauroursodeoxycholate, a chemical chaperone, prevents palmitate-induced apoptosis in pancreatic beta-cells by reducing ER stress.20130131
查看The apoptosis inhibitor ARC alleviates the ER stress response to promote beta-cell survival.20130131
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