研究主题:Diabetes, Development, Proliferation, Replication, Maintenance
详细题名日期
查看Nkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.20140408
查看Development of a conditionally immortalized human pancreatic beta cell line.20140408
查看Role of non-coding RNAs in pancreatic beta-cell development and physiology.20140408
查看Could microRNAs contribute to the maintenance of beta cell identity?20140408
查看Metabolic, hormonal characteristics, and genetic variants of TCF7L2 associated with development of gestational diabetes mellitus in Mexican women.20140408
查看Sex-dependent expression of caveolin 1 in response to sex steroid hormones is closely associated with development of obesity in rats.20140408
查看Microenvironmental stimuli for proliferation of functional islet beta-cells.20140408
查看Human beta-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.20140408
查看Treatment of new onset type 1 diabetes with teplizumab: successes and pitfalls in development.20140408
查看Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: Involvement of suppression of cell cycle progression and NF-kappaB/AP-1 pathways.20140408
查看Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a.20140408
查看The preventive role of type 2 NKT cells in the development of type 1 diabetes.20140408
查看Insulin and bone: Recent developments.20140317
查看Diabetes: Solving human beta-cell development-what does the mouse say?20140317
查看Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: Study in juvenile diabetic rat.20140317
查看Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus.20140317
查看Patterns of Obesity Development before the Diagnosis of Type 2 Diabetes: The Whitehall II Cohort Study.20140317
查看Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: Involvement of suppression of cell cycle progression and NF-kappaB/AP-1 pathways.20140317
查看Effects of glucocorticoids and exercise on pancreatic beta-cell function and diabetes development: comments on Beaudry and Riddel.20140317
查看Targeting the cell cycle inhibitor p57Kip2 promotes adult human beta cell replication.20140317
查看Transmaternal Bisphenol A Exposure Accelerates Diabetes Type 1 Development in NOD Mice.20140317
查看Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells.20140217
查看Mechanisms simultaneously regulate smooth muscle proliferation and differentiation.20140217
查看Induction of Mixed Chimerism Depletes Pre-Existing and De Novo Developed Autoreactive B cells in Autoimmune NOD Mice.20140217
查看Targeting the cell cycle inhibitor p57Kip2 promotes adult human beta cell replication.20140217
查看Analysis of Transcription Factors Key for Mouse Pancreatic Development Establishes NKX2-2 and MNX1 Mutations as Causes of Neonatal Diabetes in Man.20140217
查看Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic beta-cells.20140217
查看The Resist Diabetes trial: Rationale, design, and methods of a hybrid efficacy/effectiveness intervention trial for resistance training maintenance to improve glucose homeostasis in older prediabetic adults.20140217
查看New onset of diabetes after transplantation - An overview of epidemiology, mechanism of development and diagnosis.20140217
查看Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes.20140217
查看The PARK2 gene is involved in the maintenance of pancreatic beta-cell functions related to insulin production and secretion.20140217
查看A smad signaling network regulates islet cell proliferation.20140217
查看Soluble factors secreted by T cells promote beta-cell proliferation.20140217
查看microRNA in the development of diabetic complications.20140217
查看Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells.20140217
查看The Role of the Dysfunctional Akt-Related Pathway in Cancer: Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future Strategies for Drug Development.20140102
查看Betatrophin: A liver-derived hormone for the pancreatic beta-cell proliferation.20140102
查看Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rgamma(null) mice treated with alogliptin.20140102
查看Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting.20140102
查看Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic beta-cells.20140102
查看Initial Cell Seeding Density Influences Pancreatic Endocrine Development During in vitro Differentiation of Human Embryonic Stem Cells.20140102
查看Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes.20140102
查看Thymic Development of Autoreactive T Cells in NOD Mice Is Regulated in an Age-Dependent Manner.20140102
查看Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.20140102
查看Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes.20140102
查看Transmaternal Bisphenol A Exposure Accelerates Diabetes Type 1 Development in NOD Mice.20140102
查看The CD19 signalling molecule is elevated in NOD mice and controls type 1 diabetes development.20140102
查看The role of renin-angiotensin system in cellular differentiation: implications in pancreatic islet cell development and islet transplantation.20140102
查看The Resist Diabetes trial: Rationale, design, and methods of a hybrid efficacy/effectiveness intervention trial for resistance training maintenance to improve glucose homeostasis in older prediabetic adults.20131203
查看Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway.20131203
查看Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes.20131203
查看Growth hormone prevents the development of autoimmune diabetes.20131203
查看Thymic Development of Autoreactive T Cells in NOD Mice Is Regulated in an Age-Dependent Manner.20131203
查看Deoxyhypusine Synthase Promotes Differentiation and Proliferation of Th1 Cells in Autoimmune Diabetes.20131203
查看Transmaternal bisphenol A exposure accelerates diabetes type 1 development in NOD mice.20131203
查看Defective prolactin signaling impairs pancreatic beta-cell development during the perinatal period.20131203
查看Pancreatic beta cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene.20131203
查看Development of a cysteine-deprived and C-terminally truncated GLP-1 receptor.20131203
查看gamma-Aminobutyric Acid Regulates Both the Survival and Replication of Human beta-Cells.20131203
查看TGF-beta superfamily member nodal stimulates human beta-cell proliferation while maintaining cellular viability.20131203
查看Induction of beta-Cell Replication by a Synthetic HNF4alpha Antagonist.20131203
查看Efficient beta-Cell Regeneration by a Combination of Neogenesis and Replication Following beta-Cell Ablation and Reversal of Pancreatic Duct Ligation.20131203
查看Overnutrition Stimulates Intestinal Epithelium Proliferation Through beta-Catenin Signaling in Obese Mice.20131203
查看Ellagic acid inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and prevents atheroma formation in streptozotocin-induced diabetic rats.20131203
查看The Role of SOX9 Transcription Factor in Pancreatic and Duodenal Development.20131203
查看Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic beta-cells in a pancreatectomy model.20131104
查看Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes.20131104
查看Development and application of specific cytokine assays in tissue samples from a bottlenose dolphin with hyperinsulinemia.20131104
查看Evaluation of Estrogenic Potential of Flavonoids Using a Recombinant Yeast Strain and MCF7/BUS Cell Proliferation Assay.20131104
查看The PARK2 gene is involved in the maintenance of pancreatic beta-cell functions related to insulin production and secretion.20131104
查看A smad signaling network regulates islet cell proliferation.20131104
查看Soluble factors secreted by T-cells promote beta-cell proliferation.20131104
查看GSK-3beta function in bone regulates skeletal development, whole-body metabolism, and male life span.20131104
查看Loss of Prohibitin Induces Mitochondrial Damages Altering beta-Cell Function and Survival and Is Responsible for Gradual Diabetes Development.20131104
查看Defective prolactin signaling impairs pancreatic beta cell development during the perinatal period.20131002
查看Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction.20131002
查看Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells.20131002
查看Pancreatic beta cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene.20131002
查看Development of a cysteine-deprived and C-terminally truncated GLP-1 receptor.20131002
查看The CD19 signalling molecule is elevated in NOD mice and controls type 1 diabetes development.20131002
查看Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a.20131002
查看Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 beta-cell line.20131002
查看Elevated toll-like receptor 3 inhibits pancreatic beta-cell proliferation through G1 phase cell cycle arrest.20131002
查看Diabetes: Human beta-cell proliferation by promoting Wnt signalling.20131002
查看Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice.20131002
查看Relative contributions of insulin resistance and beta-cell dysfunction to the development of Type 2 diabetes in Koreans.20131002
查看The role of renin-angiotensin system in cellular differentiation: Implications in pancreatic islet cell development and islet transplantation.20130902
查看The preventive role of type 2 NKT cells in the development of type 1 diabetes.20130902
查看Establishment of a pancreatic beta cell proliferation model in vitro and a platform for diabetes drug screening.20130902
查看TGF-Beta Superfamily Member Nodal Stimulates Human Beta Cell Proliferation While Maintaining Cellular Viability.20130902
查看Induction of beta-cell replication by a synthetic HNF4alpha antagonist.20130902
查看Efficient beta-cell regeneration by a combination of neogenesis and replication following beta-cell ablation and reversal of pancreatic duct ligation.20130902
查看Overexpression of E2F3 promotes proliferation of functional human beta cells without induction of apoptosis.20130902
查看The Role of SOX9 Transcription Factor in Pancreatic and Duodenal Development.20130902
查看Peroxisome Proliferator-activated Receptor gamma (PPARgamma) and Its Target Genes Are Downstream Effectors of FoxO1 Protein in Islet beta-Cells: MECHANISM OF beta-CELL COMPENSATION AND FAILURE.20130902
查看Role of HDL Cholesterol and Estimates of HDL Particle Composition in Future Development of Type 2 Diabetes in the General Population: The PREVEND Study.20130902
查看Systemic Regulation of the Age-Related Decline of Pancreatic beta-Cell Replication.20130902
查看Overexpression of E2F3 promotes proliferation of functional human beta cells without induction of apoptosis.20130830
查看GSK-3beta function in bone regulates skeletal development, whole body metabolism and male life span.20130830
查看The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic beta-cells and restrict their ability to proliferate.20130830
查看Overnutrition stimulates intestinal epithelium proliferation through beta-catenin signaling in obese mice.20130830
查看Endocrine pancreatic development: impact of obesity and diet.20130830
查看Ellagic acid inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and prevents atheroma formation in streptozotocin-induced diabetic rats.20130830
查看Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line.20130830
查看Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation.20130830
查看Elevated toll-like receptor 3 inhibits pancreatic beta-cell proliferation through G1 phase cell cycle arrest.20130830
查看Betatrophin fuels beta cell proliferation: first step toward regenerative therapy?20130830
查看Diabetes: Human beta-cell proliferation by promoting Wnt signalling.20130830
查看CRTC2 is required for beta-cell function and proliferation.20130830
查看Adaptive beta-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.20130830
查看Overexpression of intraislet ghrelin enhances beta-cell proliferation after streptozotocin-induced beta-cell injury in mice.20130830
查看Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets.20130830
查看Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population.20130830
查看The role of SOX9 transcription factor in pancreatic and duodenal development.20130702
查看Lifetime congenital isolated GH deficiency does not protect from the development of diabetes.20130702
查看Targeted Overexpression of CKI-Insensitive Cyclin-Dependent Kinase 4 Increases Functional beta-Cell Number Through Enhanced Self-Replication in Zebrafish.20130702
查看Lower adiponectin levels at first trimester of pregnancy are associated with increased insulin resistance and higher risk of developing gestational diabetes mellitus.20130702
查看Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice.20130702
查看Development of A Novel Long-acting Anti-diabetic FGF21 Mimetic by Targeted Conjugation to A Scaffold Antibody.20130606
查看A Variable CD3(+) T-Cell Frequency in Peripheral Blood Lymphocytes Associated with Type 1 Diabetes Mellitus Development in the LEW.1AR1-iddm Rat.20130606
查看Role of HDL cholesterol and estimates of HDL particle composition in future development of type 2 diabetes in the general population: The PREVEND Study.20130606
查看CRTC2 is required for beta cell function and proliferation.20130606
查看Adaptive beta cell proliferation increases early in high fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.20130606
查看Genetic deletion of Granzyme B does not confer resistance to the development of spontaneous diabetes in NOD mice.20130606
查看Overexpression of intra-islet ghrelin enhances beta-cell proliferation after streptozotocin-induced beta-cell injury in mice.20130606
查看O-GlcNAcomics - Revealing Roles of O-GlcNAcylation in Disease Mechanisms and Development of Potential Diagnostics.20130606
查看Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon Treated Primary Human Pancreatic Islets.20130606
查看Betatrophin: A Hormone that Controls Pancreatic beta Cell Proliferation.20130606
查看[Cross-talk between insulin signaling and cell proliferation pathways].20130606
查看Family psychological stress early in life and development of type 1 diabetes: The ABIS prospective study.20130606
查看Predominance of beta-Cell Neogenesis Rather Than Replication in Humans With an Impaired Glucose Tolerance and Newly Diagnosed Diabetes.20130606
查看Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes.20130606
查看Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance.20130606
查看TGF-beta Signaling Regulates Pancreatic beta-Cell Proliferation through Control of Cell Cycle Regulator p27 Expression.20130430
查看Systemic regulation of the age-related decline of pancreatic beta-cell replication.20130430
查看B7-H4.Ig inhibits the development of Type 1 diabetes by regulating Th17 cells in NOD mice.20130430
查看Betatrophin: A Hormone that Controls Pancreatic beta Cell Proliferation.20130430
查看Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population.20130430
查看[Cross-talk between insulin signaling and cell proliferation pathways].20130430
查看Targeted Overexpression of CKI-Insensitive Cyclin-Dependent Kinase 4 Increases Functional beta-Cell Number Through Enhanced Self-Replication in Zebrafish.20130430
查看Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus.20130430
查看TGFbeta receptor signaling is essential for inflammation-induced but not beta-cell workload-induced beta-cell proliferation.20130430
查看Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes.20130430
查看TGF-beta Signaling Regulates Pancreatic beta-Cell Proliferation through Control of Cell Cycle Regulator p27 Expression.20130330
查看B7-H4.Ig inhibits the development of Type 1 diabetes by regulating Th17 cells in NOD mice.20130330
查看Relative contributions of insulin resistance and beta-cell dysfunction to the development of Type 2 diabetes in Koreans.20130330
查看Family psychological stress early in life and development of type 1 diabetes: The ABIS prospective study.20130330
查看Predominance of beta-cell neogenesis rather than replication in humans with an impaired glucose tolerance and newly diagnosed diabetes.20130330
查看Mechanisms of disease: inflammasome activation and the development of type 2 diabetes.20130330
查看Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes.20130330
查看Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus.20130330
查看Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish.20130330
查看Development of a cell-based high-throughput peroxisome proliferator-activated receptors (PPARs) screening model and its application for evaluation of the extracts from Rhizoma Coptis.20130330
查看Blockade of receptor activator of nuclear factor-kappaB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus.20130330
查看Glucocorticoid-induced suppression of beta-cell proliferation is mediated by Mig6.20130330
查看Novel views on new-onset diabetes after transplantation: development, prevention and treatment.20130330
查看Generating insulin-producing cells for diabetic therapy: Existing strategies and new development.20130330
查看CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.20130330
查看MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic beta-cells.20130330
查看Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish.20130228
查看Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.20130228
查看Development of a cell-based high-throughput peroxisome proliferator-activated receptors (PPARs) screening model and its application for evaluation of the extracts from Rhizoma Coptis.20130228
查看Blockade of receptor activator of nuclear factor-kappaB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus.20130228
查看Glucocorticoid-induced suppression of beta-cell proliferation is mediated by Mig6.20130228
查看Small-molecule inducer of beta cell proliferation identified by high-throughput screening.20130228
查看Development and evaluation of 18F-TTCO-Cys40-Exendin-4: a PET probe for imaging transplanted islets.20130228
查看Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice.20130228
查看Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1.20130228
查看IL-2 promotes the function of memory-like autoregulatory CD8+ T cells but suppresses their development via FoxP3+ Treg cells.20130228
查看Estrogen-induced retinal endothelial cell proliferation: possible involvement of pigment epithelium-derived factor and phosphoinositide 3-kinase/mitogen-activated protein kinase pathways.20130228
查看Overexpression of peroxisome proliferator-activated receptor alpha in pancreatic beta-cells improves glucose tolerance in diet-induced obese mice.20130228
查看Vildagliptin preserves the mass and function of pancreatic beta cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes.20130228
查看Contribution of insulin deficiency and insulin resistance to the development of type 2 diabetes: nature of early stage diabetes.20130228
查看The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development.20130131
查看Obestatin Enhances In Vitro Generation of Pancreatic Islets through Regulation of Developmental Pathways.20130131
查看A Variable CD3(+) T-Cell Frequency in Peripheral Blood Lymphocytes Associated with Type 1 Diabetes Mellitus Development in the LEW.1AR1-iddm Rat.20130131
查看Mechanisms of disease: inflammasome activation and the development of type 2 diabetes.20130131
查看Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.20130131
查看Development of a cell-based high-throughput peroxisome proliferator-activated receptors (PPARs) screening model and its application for evaluation of the extracts from Rhizoma Coptis.20130131
查看Maternal obesity during the preconception and early life periods alters pancreatic development in early and adult life in male mouse offspring.20130131
查看Effects of glycated low-density lipoprotein on cell viability, proliferation, and growth factors of mouse embryo fibroblasts.20130131
查看Small-molecule inducer of beta cell proliferation identified by high-throughput screening.20130131
查看Novel views on new-onset diabetes after transplantation: development, prevention and treatment.20130131
查看The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreas.20130131
查看Generating insulin-producing cells for diabetic therapy: Existing strategies and new development.20130131
查看Epoxypukalide induces proliferation and protects against cytokine-mediated apoptosis in primary cultures of pancreatic beta-cells.20130131
查看Lower adiponectin levels at first trimester of pregnancy are associated with increased insulin resistance and higher risk of developing gestational diabetes mellitus.20130131
查看Development and evaluation of 18F-TTCO-Cys40-Exendin-4: a PET probe for imaging transplanted islets.20130131
查看Marked decline in beta cell function during pregnancy leads to the development of glucose intolerance in Japanese women.20130131
查看High vitreous concentration of IL-6 and IL-8, but not of adhesion molecules in relation to plasma concentrations in proliferative diabetic retinopathy.20130131
查看Periodontal disease as a potential risk factor for the development of diabetes in women with a prior history of gestational diabetes mellitus.20130131
查看Trefoil factor 2 promotes cell proliferation in pancreatic beta-cells through CXCR-4-mediated ERK1/2 phosphorylation.20130131
查看IL-2 promotes the function of memory-like autoregulatory CD8+ T cells but suppresses their development via FoxP3+ Treg cells.20130131
查看The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway.20130131
查看Hyperinsulinemia-induced vascular smooth muscle cell (VSMC) migration and proliferation is mediated by converging mechanisms of mitochondrial dysfunction and oxidative stress.20130131
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