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题名:Alternanthera paronychioides protects pancreatic beta-cells from glucotoxicity by its antioxidant, antiapoptotic and insulin secretagogue actions.
作者:WU CH; HSIEH HT; LIN JA; YEN GC;
来源:Food Chem. 2013 Aug 15;139(1-4):362-70. doi: 10.1016/j.foodchem.2013.01.026. Epub [ IF= 0.00 ] ]
URL :10.1016/j.foodchem.2013.01.026
日期:20130131
摘要:The antioxidant and antiglucotoxic effects of Alternanthera paronychioides on
pancreatic beta-cell were investigated. Antioxidant assays demonstrated that
ethanol extracts of A. paronychioides (EEAP) exhibited the highest antioxidant
activity, which also had the highest phenolic and flavonoid contents. Two major
polyphenolics, ferulic acid and quercetin, were identified from EEAP by HPLC-DAD.
Effects of EEAP, ferulic acid and quercetin on high glucose (25 mmol/L)-induced
pancreatic beta-cell apoptosis and dysfunction were further evaluated. Results
showed that EEAP and quercetin but not ferulic acid protected beta-cells from
glucotoxicity through several mechanisms, including: (1) maintaining beta-cell
viability; (2) suppressing reactive oxygen species production; (3) reducing
characteristic features of apoptosis; (4) inhibiting the activation of caspase-9
and caspase-3 and the cleavage of poly (ADP-ribose) polymerase; (5) upregulating
pancreatic and duodenal homeobox 1 gene expression and the insulin secretagogue
action of pancreatic beta-cells. These findings may shed light on the preventive
actions of A. paronychioides on diabetic glucotoxicity.

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