详细记录  
题名:Iron and diabetes risk.
作者:SIMCOX JA; MCCLAIN DA;
来源:Cell Metab. 2013 Mar 5;17(3):329-41. doi: 10.1016/j.cmet.2013.02.007. [ IF= 0.00 ] ]
URL :10.1016/j.cmet.2013.02.007
日期:20130330
摘要:Iron overload is a risk factor for diabetes. The link between iron and diabetes
was first recognized in pathologic conditions-hereditary hemochromatosis and
thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays
a direct and causal role in diabetes pathogenesis mediated both by beta cell
failure and insulin resistance. Iron also regulates metabolism in most tissues
involved in fuel homeostasis, with the adipocyte in particular serving an
iron-sensing role. The underlying molecular mechanisms mediating these effects
are numerous and incompletely understood but include oxidant stress and
modulation of adipokines and intracellular signal transduction pathways.

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