详细记录  
题名:Antiapoptotic effects of cerium oxide and yttrium oxide nanoparticles in isolated rat pancreatic islets.
作者:HOSSEINI A; BAEERI M; RAHIMIFARD M; NAVAEI-NIGJEH M; MOHAMMADIRAD A; POURKHALILI N; HASSANI S; KAMALI M; ABDOLLAHI M;
来源:Hum Exp Toxicol. 2013 May;32(5):544-53. doi: 10.1177/0960327112468175. [ IF= 0.00 ] ]
URL :10.1177/0960327112468175
日期:20130606
摘要:Type I diabetes mellitus is a metabolic disease caused by the impairment of
pancreatic beta-cells mainly mediated through oxidative stress and related
apoptosis. Islets transplantation seems a promising treatment for these patients,
but during islets transplant, various types of stresses related to the isolation
and transplantation procedure compromise the function and viability of islets. We
recently hypothesized that the combination of cerium oxide (CeO2) and yttrium
oxide (Y2O3) nanoparticles with a potential free radical scavenger behavior
should be useful to make isolated islets survive until transplanted. In the
present study, oxidative stress-induced apoptosis in isolated rat pancreatic
islets exposed to hydrogen peroxide (H2O2) and the protective effects of CeO2 and
Y2O3 nanoparticles were investigated. Exposure of islets to H2O2 (50 microm, 2 h)
increased intracellular oxidant formation such as reactive oxygen species and
subsequently apoptosis and decreased viability, glucose-induced adenosine
triphosphate (ATP) production and glucose-stimulated insulin secretion.
Pretreatment with CeO2 and/or Y2O3 nanoparticles reduced the oxidant formation
and apoptosis and increased viability, glucose-induced ATP production and
glucose-stimulated insulin secretion. These results suggest that this combination
may protect beta-cell apoptosis by improving the oxidative stress-mediated
apoptotic pathway.

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]