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题名:Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions.
作者:KWON MJ; CHUNG HS; YOON CS; LEE EJ; KIM TK; LEE SH; KO KS; RHEE BD; KIM MK; PARK JH;
来源:Korean J Intern Med. 2013 May;28(3):339-46. doi: 10.3904/kjim.2013.28.3.339. Epub [ IF= 0.00 ] ]
URL :10.3904/kjim.2013.28.3.339
日期:20130606
摘要:BACKGROUNDAIMS: beta-Cell apoptosis caused by increased endoplasmic reticulum
(ER) stress is an important pathogenic component of type 2 diabetes mellitus. In
theory, sulfonylureas, used for the treatment of diabetes, can contribute to ER
stress. We assessed changes in ER stress in pancreatic beta-cells under
glucotoxic or glucolipotoxic conditions using low concentrations of the
sulfonylurea, glibenclamide (GB). METHODS: Low concentrations of GB (10 or 100
nM) were added to INS-1 cells cultured under glucotoxic or glucolipotoxic
conditions. The degree of viability, level of apoptosis and levels of markers
associated with ER stress were measured. RESULTS: Apoptosis decreased in response
to low concentrations of GB under glucolipotoxic but not glucotoxic conditions.
Most ER stress markers decreased upon the addition of GB. Under glucotoxic
conditions, changes in the levels of ER stress markers were not consistent.
However, all decreased significantly under glucolipotoxic conditions.
CONCLUSIONS: Low concentrations of GB exerted antiapoptotic effects through the
attenuation of ER stress under glucolipotoxic conditions.

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