详细记录  
题名:Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
作者:MIYAGAWA K; KONDO T; GOTO R; MATSUYAMA R; ONO K; KITANO S; KAWASAKI S; IGATA M; KAWASHIMA J; MATSUMURA T; MOTOSHIMA H; ARAKI E;
来源:Cardiovasc Diabetol. 2013 Nov 4;12(1):160. [ IF= 0.00 ] ]
URL :10.1186/1475-2840-12-160
日期:20131203
摘要:BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors modulate incretin hormones
and exert anti-diabetic effects in type 2 diabetes mellitus. Treatment with
angiotensin II type 1 receptor blockers (ARB) is a proven successful intervention
for hypertension with type 2 diabetes. The present study investigated the
combined effects of the DPP-4 inhibitor vildagliptin and the ARB valsartan in a
mouse model of type 2 diabetes. METHODS: C57BL/6 J mice fed with high-fat diet
(HFD) or db/db mice were treated with placebo, phloridzin (PHZ), vildagliptin
alone (ViL), valsartan alone (VaL) or ViL with VaL (ViLVaL) for 8 weeks. RESULTS:
Glucose metabolism was improved in response to PHZ, ViL and ViLVaL in both HFD
and db/db mice. Upon glucose challenge, ViLVaL showed the greatest suppression of
blood glucose excursions, with increased insulin secretion, in db/db mice. ViLVaL
treatment also showed an improvement of insulin sensitivity in db/db mice. Serum
inflammatory cytokines were significantly decreased, and adiponectin was highest,
in the ViLVaL group. ViLVaL improved insulin signaling and attenuated stress
signaling in liver with amelioration of hepatic steatosis due to activated fatty
acid oxidation in db/db mice. Furthermore, immunohistochemical analysis of the
pancreas revealed that the combination treatment resulted in an increased
expression of insulin and PDX-1, and increased insulin content. CONCLUSIONS: The
combination therapy of ViL and VaL improves both pancreatic beta-cell function
and insulin sensitivity, with a reduction of the inflammatory and cell stress
milieu in mouse models of T2DM. Our results suggest that this combination therapy
exerts additive or even synergistic benefits to treat T2DM.

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]