详细记录  
题名:Oral intralipid emulsion use: a novel therapeutic approach to pancreatic beta-cell injury caused by malathion toxicity in rats.
作者:TUZCU K; ALP H; OZGUR T; KARCIOGLU M; DAVARCI I; EVLIYAOGLU O; KARAKUS A; HAKIMOGLU S;
来源:Drug Chem Toxicol. 2013 Nov 4. [ IF= 0.00 ] ]
URL :10.3109/01480545.2013.838780
日期:20131203
摘要:Abstract We aimed to investigate whether oral intralipid emulsion (OIE) reduces
pancreatic beta-cell injury (PbetaCI) by chelating with malathion (M), or
increases PbetaCI by increasing M absorption in the stomach. Fifty rats were
randomly divided into six groups: control group (C); OIE administered group (L);
M-treated group (M); OIE-administered group immediately after given M (M0L);
OIE-administered group 6 hours after being given M (M6L) and OIE administered
group 12 hours after being given M (M12L). M induced PbetaCI, hyperglycemia,
temporary hyperinsulinemia and oxidative stress (OS). However, there was no
significant difference in serum levels of glucose, insulin, total oxidants (TOS)
and liver TOS between the M0L group and groups C and L. Also, insulin levels of
M12L significantly increased, compared to the M6L group. Biochemical results,
which were confirmed by histopathology, indicate that administering OIE after 6
hours and immediately after taking M may markedly prevent PbetaCI, hyperglycemia
and OS. In addition, OIE's effectiveness decreased after 6 hours and was totally
ineffective after 12 hours. We concluded that OIE may help to achieve a better
prognosis and reduce mortality rate in cases presented to the emergency
department, particularly within the first 6 hours, resulting from organophosphate
pesticide poisoning by oral ingestion.

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