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题名:Serum GGT activity and hsCRP level in patients with type 2 diabetes mellitus with good and poor glycemic control: An evidence linking oxidative stress, inflammation and glycemic control.
作者:GOHEL MG; CHACKO AN;
来源:J Diabetes Metab Disord. 2013 Dec 20;12(1):56. [ IF= 0.00 ] ]
URL :10.1186/2251-6581-12-56
日期:20140217
摘要:BACKGROUND: Diabetes is undoubtedly one of the most challenging health problems
in 21st century. Understanding the pathogenesis and preventing long term
complications have been major goals of research in diabetes mellitus (DM).
Research in the past few years has linked oxidative stress and inflammation to
beta cell dysfunction. Aim of this study is to evaluate serum gamma-glutamyl
transferase (GGT) activity (marker of oxidative stress) and high sensitivity C
reactive protein (hsCRP) level (an inflammatory marker) in type 2 DM subjects
with good and poor glycemic control. Further, we investigated correlation between
serum GGT and hsCRP level with glycemic control (FBS, PP2BS, HbA1c) in subjects.
METHODS: A cross sectional study consists of 150 patients out of them 50 patients
having type 2 DM with good control (Group II), 50 patients with type 2 DM with
poor control (Group III) and 50 normal healthy control (Group I) were selected.
Serum GGT, serum hsCRP, FBS, PP2BS, HbA1c, and other biochemical investigations
include serum liver enzymes and lipids were measured. RESULTS: Mean serum GGT and
hsCRP concentration were statistically significantly higher in group III patients
compared to group I and group II subjects as well as increased in group II
compared to group I (p < 0.001). Further significant positive correlation was
observed between GGT and hsCRP concentration as well as both with HbA1c, FBS, and
PP2BS. CONCLUSIONS: Oxidative stress and inflammation appears to be a key
component and also associated with poor glycemic control and further pathogenesis
of diabetes and its complications. All our finding suggesting a link between
oxidative stress, inflammation and glycemic control in patient with type 2
diabetes mellitus.

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