详细记录  
题名:Thioredoxin-Interacting Protein Stimulates its Own Expression via a Positive Feedback Loop.
作者:CHEN J; JING G; XU G; SHALEV A;
来源:Mol Endocrinol. 2014 Mar 14:me20141041. [ IF= 0.00 ] ]
URL :10.1210/me.2014-1041
日期:20140408
摘要:Thioredoxin-interacting protein (TXNIP) has emerged as a key regulator of
important cellular processes including redox state, inflammation and apoptosis
and plays a particularly critical role in pancreatic beta cell biology and
diabetes development. High glucose and diabetes induce TXNIP expression, whereas
inhibition of TXNIP expression or TXNIP-deficiency protect against pancreatic
beta cell apoptosis and diabetes. We now have discovered that TXNIP stimulates
its own expression by promoting dephosphorylation and nuclear translocation of
its transcription factor, carbohydrate response element-binding protein (ChREBP)
resulting in a positive feedback loop as well as regulation of other ChREBP
target genes playing important roles in glucose and lipid metabolism. Considering
the detrimental effects of elevated TXNIP in beta cell biology, this novel
pathway sheds new light onto the vicious cycle of increased TXNIP, leading to
even more TXNIP expression, oxidative stress, inflammation, beta cell apoptosis
and diabetes progression. Moreover, the results demonstrate for the first time
that TXNIP modulates ChREBP activity and thereby uncover a previously
unappreciated link between TXNIP signaling and cell metabolism.

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]