详细记录  
题名:The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.
作者:BAHMANI F; KARAMALI M; SHAKERI H; ASEMI Z;
来源:Clin Endocrinol (Oxf). 2014 Mar 15. doi: 10.1111/cen.12451. [ IF= 0.00 ] ]
URL :10.1111/cen.12451
日期:20140408
摘要:OBJECTIVE: This study was conducted to determine the effects of folate
supplementation on inflammatory factors and biomarkers of oxidative stress among
women with polycystic ovary syndrome (PCOS). DESIGN, PATIENTS AND MEASUREMENTS:
This randomized double-blind placebo-controlled clinical trial was conducted
among 69 women diagnosed with PCOS and aged 18-40 year old. Participants were
randomly assigned to three groups receiving: 1) Folate-1: 1 mg/d folate
supplements (N=23); 2) Folate-5: 5 mg/d folate supplements (N=23) and 3) placebo
(N=23) for 8 weeks. Fasting blood samples were taken at the beginning of the
study and after 8 weeks to measure homocysteine (Hcy), inflammatory factors
including high sensitivity C-reactive protein (hs-CRP), nitric oxide (NO),
biomarkers of oxidative stress including total antioxidant capacity (TAC),
glutathione (GSH), malondialdehyde (MDA) and homeostatic model assessment-beta
cell function (HOMA-B). RESULTS: Supplementation with 5mg/d folate resulted in
reduced plasma Hcy (-2.23 vs -1.86 and 1.16 mumol/L, respectively, P<0.05),
HOMA-B (-7.63 vs 1.43 and 13.66, respectively, P<0.05), serum hs-CRP (-212.2 vs
-262.4 and 729.8 mug/L, respectively, P<0.05) and plasma MDA concentrations
(-0.48 vs -0.24 and 0.69 mumol/L, respectively, P<0.01) compared with folate-1
and placebo groups. Furthermore, a significant rise in plasma TAC (0.64 vs -3.53
and -215.47 mmol/L, respectively, P<0.01) and GSH levels (162.1 vs 195.8 and
-158.2 mumol/L, respectively, P<0.01) was also observed following the
administration of 5 mg/d folate supplements compared with folate-1 and placebo
groups. CONCLUSIONS: In conclusion, folate supplementation (5 mg/d) in women with
PCOS had beneficial effects on inflammatory factors and biomarkers of oxidative
stress. This article is protected by copyright. All rights reserved.

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