详细记录  
题名:Intra-islet glucagon secretion and action in the regulation of glucose homeostasis.
作者:WANG Q; LIANG X; WANG S;
来源:Front Physiol. 2012;3:485. doi: 10.3389/fphys.2012.00485. Epub 2013 Jan 3. [ IF= 0.00 ] ]
URL :10.3389/fphys.2012.00485
日期:20130131
摘要:Glucagon, a key hormone in the regulation of glucose homeostasis, acts as a
counter-regulatory hormone to insulin by promoting hepatic glucose output. Under
normal conditions, insulin and glucagon operate in concert to maintain the
glucose level within a narrow physiological range. In diabetes, however, while
insulin secretion or action is insufficient, the production and secretion of
glucagon are excessive, contributing to the development of diabetic
hyperglycemia. Within an islet, intra-islet insulin, in cooperation with
intra-islet GABA, suppresses glucagon secretion via direct modulation of
alpha-cell intracellular signaling pathways involving Akt activation, GABA
receptor phosphorylation and the receptor plasma membrane translocation, while
intra-islet glucagon plays an important role in modulating beta-cell function and
insulin secretion. Defects in the insulin-glucagon fine-tuning machinery may
result in beta-cell glucose incompetence, leading to unsuppressed glucagon
secretion and subsequent hyperglycemia, which often occur under extreme
conditions of glucose influx or efflux. Therefore, deciphering the precise
molecular mechanisms underlying glucagon secretion and action will facilitate our
understanding of glucagon physiology, in particular, its role in regulating islet
beta-cell function, and hence the mechanisms behind glucose homeostasis.

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