题名：The impact of a family history of type 2 diabetes on insulin secretion and insulin sensitivity in individuals with varying glucose tolerance.
作者：LI P; ZHANG JF; LI L; LIU YH; SHI Y; WANG LW; GAO JQ; LIU C;
来源：Am J Med Sci. 2013 Jan;345(1):22-7. doi: 10.1097/MAJ.0b013e31824c7a12. [ IF= 0.00 ] ]
摘要：INTRODUCTION: This study was performed to investigate the impact of a family
history of type 2 diabetes (T2DM) on insulin resistance and beta-cell dysfunction
in populations with varying glucose tolerance. METHODS: Among the total of 142
participants, 73 subjects with no family history of T2DM (FH-) included 42 with
normal glucose tolerance (NGT/FH-) and 31 with impaired glucose tolerance
(IGT/FH-); and 69 first-degree relatives of patients with T2DM (FH+) included 36
with NGT (NGT/FH+) and 33 with IGT (IGT/FH+). Insulin resistance was evaluated by
Insulin Sensitivity Index (ISI) based on the euglycemic hyperinsulinemic clamp.
Islet beta-cell function was assessed by disposition index (DI) for the acute
insulin response to glucose (AIRg) using intravenous glucose tolerance test.
Metabolic data were compared between groups after adjustment for age, sex, body
mass index and waist-to-hip ratio. RESULTS: The NGT/FH+ group showed lower level
of ISI (P = 0.023) than the NGT/FH- group, whereas no difference was found in
AIRg or DI between these 2 subgroups. In the FH- individuals, both ISI and DI of
the IGT/FH- group decreased compared with the NGT/FH- group (both P < 0.05). In
the FH+ individuals, no difference was found in ISI between the IGT/FH+ and
NGT/FH+ groups, whereas the IGT/FH+ group had a lower level of AIRg and DI than
the NGT/FH+ group (both P < 0.0001). CONCLUSIONS: This study showed that the
pathophysiological changes were different between individuals with and without a
family history of T2DM during the glucose tolerance aggravation.