详细记录  
题名:Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study.
作者:BOT M; POUWER F; DE JONGE P; NOLAN JJ; MARI A; HOJLUND K; GOLAY A; BALKAU B; DEKKER JM;
来源:Diabetes Metab. 2013 Feb;39(1):42-9. doi: 10.1016/j.diabet.2012.09.005. Epub 2012 [ IF= 0.00 ] ]
URL :10.1016/j.diabet.2012.09.005
日期:20130228
摘要:AIM: This study explored the association of depressive symptoms with indices of
insulin sensitivity and insulin secretion in a cohort of non-diabetic men and
women aged 30 to 64 years. METHODS: The study population was derived from the
3-year follow-up of the Relationship between Insulin Sensitivity and
Cardiovascular Disease Risk (RISC) study. Presence of significant depressive
symptoms was defined as a Center for Epidemiologic Studies Depression Scale
(CES-D) score >/= 16. Standard oral glucose tolerance tests were performed.
Insulin sensitivity was assessed with the oral glucose insulin sensitivity (OGIS)
index. Insulin secretion was estimated using three model-based parameters of
insulin secretion (beta-cell glucose sensitivity, the potentiation factor ratio,
and beta-cell rate sensitivity). RESULTS: A total of 162 out of 1027 participants
(16%) had significant depressive symptoms. Having significant depressive symptoms
was not related to either OGIS [standardized beta (beta) -0.033; P=0.24] or
beta-cell glucose sensitivity (beta -0.007; P=0.82). Significant depressive
symptoms were related to decreased beta-cell rate sensitivity (odds ratio for
significant depressive symptoms of the lowest vs. highest quartile of beta-cell
rate sensitivity was 2.04; P=0.01). Also, significant depressive symptoms were
associated with a statistically significant decrease in the potentiation factor
ratio in unadjusted models, but not in the fully adjusted model. CONCLUSION:
Depressive symptoms were not related to insulin sensitivity and tended to be
weakly associated to some parameters of insulin secretion in non-diabetic
individuals. Prospective studies are needed to study the temporal association
between depression and insulin secretion.

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