详细记录  
题名:The effect of chromium on inflammatory markers, 1st and 2nd phase insulin secretion in type 2 diabetes.
作者:CHEN YL; LIN JD; HSIA TL; MAO FC; HSU CH; PEI D;
来源:Eur J Nutr. 2013 Mar 14. [ IF= 0.00 ] ]
URL :10.1007/s00394-013-0508-8
日期:20130330
摘要:OBJECTIVE: Impaired insulin sensitivity (SI) and beta-cell function are the two
main causes of type 2 diabetes (T2D) and are related to low-grade inflammation
status. Trivalent chromium has shown to improve SI in our previous study. This
might be due to the ability of decreasing interleukin-6 (IL-6) and tumor necrosis
factor alpha (TNF-alpha) shown in animal studies. In the current study, we
measured SI, beta-cell function, and plasma levels of IL-6 and TNF-alpha after
treatment of chromium chloride (GaCr) in T2D. RESEARCH DESIGN AND METHODS:
Sixty-six patients were randomly assigned to the 20 g of GaCr milk powder
studying group or the milk powder placebo group. Oral glucose tolerance test was
performed before and after the treatment. The SI and the beta-cell function were
measured as well. RESULTS: The SI was significantly improved. At the same time,
the static insulin responsivity index (Phis) was significantly higher after the
treatment (p = 0.003). On the other hand, the dynamic insulin responsivity index
(Phid) remained unchanged. Interestingly, a significant decrease in the IL-6
level after the treatment (p = 0.015) was noted. Although there was a trend of
decreasing in TNF-alpha, it was not statistically significant. Finally, there was
no significant correlation between the delta-IL-6, SI, and Phid after GaCr
treatment. CONCLUSIONS: In conclusion, other than the improvement of SI, GaCr
could also improve the second phase of insulin responsivity (Phis) and IL-6.
However, delta-IL-6 was correlated with neither delta-SI nor delta-Phis which
indicated that the improvement of SI and Phis might involve mechanisms other than
lower inflammatory effect.

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