详细记录  
题名:Increasing glucagon secretion could antagonize the action of exogenous insulin for glycemic control in streptozocin-induced diabetic rhesus monkeys.
作者:HE S; WANG D; LU Y; CHEN Y; JIN X; WANG C; ZHAO J; REN Y; WANG L; LI H; CHENG J;
来源:Exp Biol Med (Maywood). 2013 Apr 1;238(4):385-91. doi: 10.1177/1535370213477974. [ IF= 0.00 ] ]
URL :10.1177/1535370213477974
日期:20130430
摘要:Although intraislet insulin signaling is known to play a critical role in
regulating glucagon secretion, it is unknown whether abnormal glucagon secretion
influences the hypoglycemic effect of exogenous insulin with intraislet insulin
deletion. We performed a longitudinal study using 16 streptozocin (STZ)-induced
diabetic rhesus monkeys to explore alpha-cell function under the absence
beta-cells and to assess whether increasing glucagon secretion antagonizes the
action of exogenous insulin for glycemic control. We found that although the
alpha-cells were impaired and the basal secretion levels of glucagon decreased
rapidly after STZ (80-90 mg/kg) administration, as based on long-term observation
post-STZ injection, glucagon secretion and the number of alpha-cells were
increased. Glycemic control was increasingly difficult, the insulin resistance
(HOMA-IR) index was significantly higher, and the triglycerides (TG) levels were
gradually decreased. Moreover, a significant correlation between the levels of
glucagon and HOMA-IR was found. Under the long-term absence of beta-cells, the
inhibitory effect on alpha-cell activity is profoundly attenuated, leading to an
increase in glucagon secretion and the amount of alpha-cells and even alpha-cell
dysfunction. Increased glucagon levels have a serious impact on the insulin
sensitivity in vivo and result in an antagonization of the hypoglycemic effect of
exogenous insulin.

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