详细记录  
题名:Compound K, a final intestinal metabolite of ginsenosides, enhances insulin secretion in MIN6 pancreatic beta-cells by upregulation of GLUT2.
作者:GU J; LI W; XIAO D; WEI S; CUI W; CHEN W; HU Y; BI X; KIM Y; LI J; DU H; ZHANG M; CHEN L;
来源:Fitoterapia. 2013 Jun;87:84-8. doi: 10.1016/j.fitote.2013.03.020. Epub 2013 Apr [ IF= 1.85 ] ]
URL :10.1016/j.fitote.2013.03.020
日期:20130430
摘要:Compound K (CK) is a final intestinal metabolite of protopanaxadiol-type
ginsenosides from Panax ginseng and shows various bioactivities. Although it has
also been found to have the property of anti-diabetes, the long-term effect of CK
on insulin secretion in beta-cells is still unclear. In this study, CK was
prepared from ginsenoside Rd by snailase hydrolysis and its effect on the insulin
secretion activity in MIN6 pancreatic beta-cell lines in vitro was assessed. The
expression of glucose transporter isoform-2 (GLUT2) and the cellular ATP content
were also examined by western blot and HPLC analysis, respectively. The results
showed that CK significantly enhanced insulin secretion, increased cellular ATP
content, and upregulated the expression of GLUT2. These findings indicate that CK
exerts prominent stimulatory effects on insulin secretion in the MIN6 cells
partly via upregulating the expression of GLUT2.

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