题名：Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance.
作者：YANG SJ; KIM TN; BAIK SH; KIM TS; LEE KW; NAM M; PARK YS; WOO JT; KIM YS; KIM SH;
来源：Korean J Intern Med. 2013 May;28(3):306-13. doi: 10.3904/kjim.2013.28.3.306. Epub [ IF= 0.00 ] ]
摘要：BACKGROUNDAIMS: The aim was to compare the insulin sensitivity and secretion
index of pregnant Korean women with normal glucose tolerance (NGT), gestational
impaired glucose tolerance (GIGT; only one abnormal value according to the
Carpenter and Coustan criteria), and gestational diabetes mellitus (GDM).
METHODS: A cross-sectional study was performed with 1,163 pregnant women with
positive (1-hour plasma glucose >/= 7.2 mmol/L) in a 50-g oral glucose challenge
test (OGCT). The 100-g oral glucose tolerance test (OGTT) was used to stratify
the participants into three groups: NGT (n = 588), GIGT (n = 294), and GDM (n =
281). RESULTS: The GDM group had higher homeostasis model assessment of insulin
resistance and lower insulin sensitivity index (ISOGTT), quantitative insulin
sensitivity check index, homeostasis model assessment for estimation of index
beta-cell secretion (HOMA-B), first and second phase insulin secretion, and
insulin secretion-sensitivity index (ISSI) than the NGT group (p = 0.001 for
all). Moreover, the GIGT group had lower ISOGTT, HOMA-B, first and second phase
insulin secretion, and ISSI than the NGT group (p < 0.001 for all). Among the
GIGT subjects, the 1-hour plasma glucose abnormal levels group showed
significantly greater weight gain during pregnancy and higher values in the 50-g
OGCT than the other two groups. Moreover, the 1-hour and 2-hour abnormal levels
groups had poorer insulin secretion status than the 3-hour abnormal levels group.
CONCLUSIONS: Korean women with GDM show impairments of both insulin secretion and
insulin sensitivity. In addition, GIGT is associated with both beta-cell
dysfunction and insulin resistance.