详细记录  
题名:Effects of HDL Elevation with CETP Inhibition on Insulin Secretion.
作者:SIEBEL AL; NATOLI AK; YAP FY; CAREY AL; REDDY-LUTHMOODOO M; SVIRIDOV D; WEBER CI; MENESES-LORENTE G; MAUGEAIS C; FORBES JM; KINGWELL BA;
来源:Circ Res. 2013 May 15. [ IF= 0.00 ] ]
URL :10.1161/CIRCRESAHA.113.300689
日期:20130606
摘要:Rationale: High-density lipoprotein (HDL) cholesterol elevation via cholesteryl
ester transfer protein (CETP) inhibition represents a novel therapy for
atherosclerosis, which may also have relevance for type 2 diabetes. Objective:
The current study assessed the effects of a CETP inhibitor (CETPi) on
postprandial insulin, ex vivo insulin secretion and cholesterol efflux from
pancreatic beta-cells. Methods and Results: Healthy participants received a daily
dose of CETPi (n=10) or placebo (n=15) for 14 days in a randomized, double-blind
study. Insulin secretion and cholesterol efflux from MIN6N8 beta-cells was
determined following incubation with treated plasma. CETP inhibition increased
plasma HDL cholesterol, apoAI and postprandial insulin. MIN6N8 beta-cells
incubated with plasma from CETPi-treated individuals (vs placebo) exhibited an
increase in both glucose-stimulated insulin secretion (GSIS) and cholesterol
efflux over the 14 day treatment period. Conclusions: CETP inhibition increased
postprandial insulin and promoted ex vivo beta-cell GSIS, potentially via
enhanced beta-cell cholesterol efflux.

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