题名：Differences in insulin secretion and sensitivity in short-sleep insomnia.
作者：VASISHT KP; KESSLER LE; BOOTH JN 3RD; IMPERIAL JG; PENEV PD;
来源：Sleep. 2013 Jun 1;36(6):955-7. doi: 10.5665/sleep.2734. [ IF= 5.05 ] ]
摘要：OBJECTIVE: Short-sleep insomnia is associated with increased risk of diabetes.
The role of altered insulin secretion and action in this association is poorly
understood. DESIGN: Observational study. SETTING: Academic clinical research
center. PARTICIPANTS: Nondiabetic individuals with insomnia (mean [standard
deviation] age 48  y, body mass index 25.6 [3.9] kg/m(2)) with = 6 h (short
sleep, n = 14) and > 6 h of sleep (n = 14) during overnight laboratory
polysomnography. MEASUREMENTS AND RESULTS: Standard oral glucose testing was used
to assess glucose tolerance, beta-cell function (homeostasis model assessment
[HOMA-B]; second-phase insulin secretion) and insulin resistance (HOMA-IR;
insulin sensitivity index). There was no significant difference in hemoglobin A1C
and fasting or 2-h blood glucose concentrations between sleep groups. Short-sleep
insomnia sufferers had lower fasting and postchallenge serum insulin
concentrations associated with lower estimates of fasting and glucose-stimulated
insulin secretion, and increased insulin sensitivity. CONCLUSIONS: Individuals
with short-sleep insomnia appear to have higher indices of systemic insulin
sensitivity and secrete less insulin without changes in overall glucose
tolerance. CITATION: Vasisht KP; Kessler LE; Booth JN; Imperial JG; Penev PD.
Differences in insulin secretion and sensitivity in short-sleep insomnia. SLEEP