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题名:A SNP in G6PC2 predicts insulin secretion in type 1 diabetes.
作者:SANDA S; WEI S; RUE T; SHILLING H; GREENBAUM C;
来源:Acta Diabetol. 2013 Jun;50(3):459-62. doi: 10.1007/s00592-012-0389-y. Epub 2012 [ IF= 0.00 ] ]
URL :10.1007/s00592-012-0389-y
日期:20130702
摘要:We investigated whether single nucleotide polymorphisms in genes related to
glucose metabolism correlate with insulin secretion in type 1 diabetes patients.
A cohort of 49 type 1 diabetes patients underwent serial mixed meal tolerance
tests to assess insulin secretion. Patients were genotyped for SNPs related to
glucose metabolism: CDKAL1 rs7754840, G6PC2 rs560887, HHEX rs1111875, KCNJ11
rs5215. Recently diagnosed patients (<100 days) homozygous for the G allele of
G6PC2 had higher area under the curve C-peptide on mixed meal tolerance tests
compared to non-homozygous patients (344.8 +/- 203.2 vs. 167.9 +/- 131.5, p =
0.04). Other SNPs did not correlate with insulin secretion in the new onset
period. In a longitudinal survival analysis, homozygosity for the minor allele
(A) in G6PC2 predicted more rapid loss of insulin secretion over time. A SNP in
the beta cell gene G6PC2 may correlate with preserved insulin secretion in type 1
diabetes.

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