详细记录  
题名:The role of adiponectin as a compensatory mediator for the primary secretory defect in latent autoimmune diabetes in adults.
作者:HATZIAGELAKI E; LAMBADIARI V; TSIAVOU A; GOGAS H; BRETZEL RG; DIMITRIADIS G;
来源:Clin Ther. 2013 Jul;35(7):1016-24. doi: 10.1016/j.clinthera.2013.06.001. [ IF= 0.00 ] ]
URL :10.1016/j.clinthera.2013.06.001
日期:20130830
摘要:BACKGROUND: Increased adiposity in patients with newly diagnosed type 2 diabetes
mellitus (DM), as well as in patients who do not have DM, affects the regulation
of insulin sensitivity and the metabolic effects of adiponectin. OBJECTIVE: The
goal of this study was to investigate the relationship between plasma adiponectin
levels and obesity in patients developing DM mainly due to an early decline in
beta-cell function. METHODS: We studied 29 patients with latent autoimmune
diabetes in adults (LADA), 38 patients with type 1 DM, and 55 healthy volunteers.
RESULTS: Plasma adiponectin levels, adjusted for body mass index (BMI), were
higher in patients with type 1 DM than in controls (P < 0.001) and similar to
those in patients with LADA (P = 0.464). Plasma adiponectin levels were higher in
LADA patients compared with controls (P < 0.001). In LADA patients, plasma
adiponectin levels, adjusted for BMI, correlated significantly with insulin
resistance (beta coefficient, -6.453 [2.772]; P = 0.028). Interestingly, this
relationship in LADA patients was significant in more overweight patients (beta
coefficient, -7.142 [3.249]; P = 0.048) but not in leaner patients (P = 0.571), a
finding that was not confirmed through the results in the controls (P = 0.520 and
P = 0.992, respectively). CONCLUSIONS: In patients with LADA, increases in plasma
adiponectin levels, after adjustment for BMI, could act as a mediator for
improvement in insulin sensitivity and thus compensate for the primary secretory
defect. This effect seems more profound in more overweight subjects than in
leaner subjects.

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