详细记录  
题名:Relationship of body mass index and GAD65 antibody status on beta-cell secretion at diabetes onset in African-American children.
作者:BALIKCIOGLU PG; BALIKCIOGLU M; GOMEZ R; VARGAS A; CHALEW SA;
来源:J Pediatr Endocrinol Metab. 2013 Jul 6:1-5. doi: 10.1515/jpem-2013-0138. [ IF= 0.00 ] ]
URL :10.1515/jpem-2013-0138
日期:20130830
摘要:Abstract Body mass and anti-pancreatic antibody status potentially influences the
presentation of diabetes in children. We hypothesized that anti-pancreatic
auto-antibody positive patients with new onset diabetes would have lower levels
of insulin and C-peptide at presentation, and hence higher HbA1c. Records of
children with new onset diabetes self-identified as African American were
retrospectively analyzed. Patients were under 19 years of age. Anti-GAD65
antibody titer, HbA1c, blood glucose, insulin and C-peptide levels were drawn at
the time of diagnosis. Patients were classified as antibody positive if
anti-GAD65 was >/=0.5. HbA1c, insulin and C-peptide levels were considered as
dependent variables in statistical models that included auto-antibody status,
gender, age, body mass index z score (BMI-z score), and blood glucose as
independent covariates. Records of 61 African-American children were available
for analysis. There was no statistical association of auto-antibody status or
initial clinical diagnosis with HbA1c, insulin or C-peptide level. BMI-z score
was strongly associated with insulin (p=0.0006) and C-peptide (p<0.0001) levels.
In general, higher BMI-z score, female gender and older age were associated with
higher C-peptide levels. Although potentially helpful in eventually determining
etiology, pancreatic auto-antibody levels do not have an association with HbA1c,
insulin or C-peptide levels in African-American children with new onset diabetes.
BMI-z score had the most robust association with insulin and C-peptide levels at
presentation.

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