详细记录  
题名:Effects of high-density lipoprotein elevation with cholesteryl ester transfer protein inhibition on insulin secretion.
作者:SIEBEL AL; NATOLI AK; YAP FY; CAREY AL; REDDY-LUTHMOODOO M; SVIRIDOV D; WEBER CI; MENESES-LORENTE G; MAUGEAIS C; FORBES JM; KINGWELL BA;
来源:Circ Res. 2013 Jul 5;113(2):167-75. doi: 10.1161/CIRCRESAHA.113.300689. Epub 2013 [ IF= 0.00 ] ]
URL :10.1161/CIRCRESAHA.113.300689
日期:20130830
摘要:RATIONALE: High-density lipoprotein cholesterol elevation via cholesteryl ester
transfer protein (CETP) inhibition represents a novel therapy for
atherosclerosis, which also may have relevance for type 2 diabetes mellitus.
OBJECTIVE: The current study assessed the effects of a CETP inhibitor on
postprandial insulin, ex vivo insulin secretion, and cholesterol efflux from
pancreatic beta-cells. METHODS AND RESULTS: Healthy participants received a daily
dose of CETP inhibitor (n=10) or placebo (n=15) for 14 days in a randomized
double-blind study. Insulin secretion and cholesterol efflux from MIN6N8
beta-cells were determined after incubation with treated plasma. CETP inhibition
increased plasma high-density lipoprotein cholesterol, apolipoprotein AI, and
postprandial insulin. MIN6N8 beta-cells incubated with plasma from CETP
inhibitor-treated individuals (compared with placebo) exhibited an increase in
both glucose-stimulated insulin secretion and cholesterol efflux over the 14-day
treatment period. CONCLUSIONS: CETP inhibition increased postprandial insulin and
promoted ex vivo beta-cell glucose-stimulated insulin secretion, potentially via
enhanced beta-cell cholesterol efflux.

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