详细记录  
题名:Metabolic signaling in fuel-induced insulin secretion.
作者:PRENTKI M; MATSCHINSKY FM; MADIRAJU SR;
来源:Cell Metab. 2013 Aug 6;18(2):162-85. doi: 10.1016/j.cmet.2013.05.018. Epub 2013 [ IF= 0.00 ] ]
URL :10.1016/j.cmet.2013.05.018
日期:20130902
摘要:The pancreatic islet beta cell senses circulating levels of calorigenic nutrients
to secrete insulin according to the needs of the organism. Altered insulin
secretion is linked to various disorders such as diabetes, hypoglycemic states,
and cardiometabolic diseases. Fuel stimuli, including glucose, free fatty acids,
and amino acids, promote insulin granule exocytosis primarily via their
metabolism in beta cells and the production of key signaling metabolites. This
paper reviews our current knowledge of the pathways involved in both positive and
negative metabolic signaling for insulin secretion and assesses the role of
established and candidate metabolic coupling factors, keeping recent developments
in focus.

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