详细记录  
题名:Effect of insulin glargine on endogenous insulin secretion and beta-cell function in Japanese type 2 diabetic patients using oral antidiabetic drugs.
作者:OHTA A; KATO H; MURAYAMA K; HASHIMOTO E; MURAKAMI M; NISHINE A; OHSHIGE T; SADA Y; ASAI S; KAWATA T; NAGAI Y; KATABAMI T; TANAKA Y;
来源:Endocr J. 2013 Sep 22. [ IF= 0.00 ] ]
URL :N U L L
日期:20131002
摘要:The aim of the present study was to evaluate the effect of insulin glargine (Gla)
(as part of basal-supported oral therapy) on endogenous insulin secretion and
beta-cell function in type 2 diabetic patients. In 33 insulin-naive patients
showing poor glycemic control on treatment with sulfonylurea (SU)-based OADs
without DPP4 inhibitors, once-daily injection of Gla was added without changing
OADs, and the dose of Gla was titrated to attain a fasting plasma glucose (FPG)
<110 mg/dL over 24 weeks. Morning meal tests were done at baseline, 12 weeks and
24 weeks. FPG and 2-hour plasma glucose (2HPG) and serum C-peptide (FCPR and
2HCPR) were measured 3 times, while serum intact proinsulin (FPI and 2HPI) was
measured at baseline and 24 weeks. Levels of FPG, FCPR, 2HPG, and HbA1c were
significantly reduced from baseline at 24 weeks (176+/-52 to 117+/-27 mg/dL,
p<0.01; 2.0+/-0.9 to 1.6+/-1.0 ng/mL, p<0.01; 257+/-53 to 202+/-27 mg/dL, p<0.01;
and 8.4+/-0.9 to 7.3+/-0.6%, p<0.01, Mean+/-SD), but 2HCPR was unchanged. The
patients were divided into two groups depending on whether FPG at 24 weeks was
<110 mg/dL or not (attained group (n=15) and not attained group (n=18)). The dose
of Gla did not differ between the two groups, but the 2HPI/2HCPR ratio at 24
weeks showed a significant decrease from baseline in the attained group.
Supplementation with Gla improved glycemic control and maintained intrinsic basal
insulin secretion, without changing 2-hour postprandial secretion. Achieving good
glycemic control with an FPG<110 mg/dL by adding Gla decreased the 2HPI/2HCPR
ratio at 24 weeks.

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