详细记录  
题名:Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS.
作者:PEINADO JR; SAMI F; RAJPUROHIT N; LINDBERG I;
来源:FEBS Lett. 2013 Sep 13. pii: S0014-5793(13)00691-1. doi: [ IF= 0.00 ] ]
URL :10.1016/j.febslet.2013.09.006
日期:20131002
摘要:The deposition of fibrillated human islet beta-cell peptide islet amyloid
polypeptide (hIAPP) into amyloid plaques is characteristic of the pathogenesis of
islet cell death during type 2 diabetes. We investigated the effects of the
neuroendocrine secretory proteins 7B2 and proSAAS on hIAPP fibrillation in vitro
and on cytotoxicity. In vitro, 21-kDa 7B2 and proSAAS blocked hIAPP fibrillation.
Structure-function studies showed that a central region within 21-kDa 7B2 is
important in this effect and revealed the importance of the N-terminal region of
proSAAS. Both chaperones blocked the cytotoxic effects of exogenous hIAPP on
Rin5f cells; 7B2 generated by overexpression was also effective. ProSAAS and 7B2
may perform a chaperone role as secretory anti-aggregants in normal islet cell
function and in type 2 diabetes.

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