详细记录  
题名:Sphingomyelin Patches on Pancreatic Beta-cells Are Indicative of Insulin Secretory Capacity.
作者:KAVISHWAR A; MOORE A;
来源:J Histochem Cytochem. 2013 Sep 25. [ IF= 0.00 ] ]
URL :10.1369/0022155413502792
日期:20131002
摘要:The establishment and validation of specific markers on the surfaces of
pancreatic beta-cells would have a significant impact on the development of
agents that specifically target these cells for imaging and/or image-guided
therapy in diabetes patient samples. We have recently described unique,
cholesterol-stabilized sphingomyelin (SM) patches on the surfaces of beta-cells
using the IC2 antibody. To further investigate the utility of SM patches as a
unique beta-cell biomarker, we embarked on the current study to correlate the
expression of this antigen with the insulin secretory capacity of beta-cells in
tissue samples from patients and animals with type 1 and type 2 diabetes and
compared this with samples from normal subjects. We found that the locations of
SM patches were consistent with the insulin status of islets in all tissues
studied. Using immunohistochemistry and staining with an IC2 antibody, we
demonstrated a direct correlation between the reduced expression of SM patches
and insulin production in diabetic individuals, indicating that the former could
potentially serve as a functional biomarker of beta-cells. We believe that our
results have significant implications for the further development of ligands with
SM specificity for the non-invasive functional assessment of beta-cells and/or
for targeted therapeutic delivery in diabetic patients.

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