详细记录  
题名:Geniposide Regulates Glucose-Stimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS-1 Cells.
作者:LIU J; GUO L; YIN F; ZHANG Y; LIU Z; WANG Y;
来源:PLoS One. 2013 Oct 22;8(10):e78315. doi: 10.1371/journal.pone.0078315. [ IF= 3.73 ] ]
URL :10.1371/journal.pone.0078315
日期:20131104
摘要:Glucose-stimulated insulin secretion (GSIS) is essential to the control of
metabolic fuel homeostasis. The impairment of GSIS is a key element of beta-cell
failure and one of causes of type 2 diabetes mellitus (T2DM). Although the KATP
channel-dependent mechanism of GSIS has been broadly accepted for several
decades, it does not fully describe the effects of glucose on insulin secretion.
Emerging evidence has suggested that other mechanisms are involved. The present
study demonstrated that geniposide enhanced GSIS in response to the stimulation
of low or moderately high concentrations of glucose, and promoted glucose uptake
and intracellular ATP levels in INS-1 cells. However, in the presence of a high
concentration of glucose, geniposide exerted a contrary role on both GSIS and
glucose uptake and metabolism. Furthermore, geniposide improved the impairment of
GSIS in INS-1 cells challenged with a high concentration of glucose. Further
experiments showed that geniposide modulated pyruvate carboxylase expression and
the production of intermediates of glucose metabolism. The data collectively
suggest that geniposide has potential to prevent or improve the impairment of
insulin secretion in beta-cells challenged with high concentrations of glucose,
likely through pyruvate carboxylase mediated glucose metabolism in beta-cells.

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