详细记录  
题名:Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery.
作者:HOLST JJ;
来源:Curr Opin Pharmacol. 2013 Oct 22. pii: S1471-4892(13)00187-2. doi: [ IF= 0.00 ] ]
URL :10.1016/j.coph.2013.09.014
日期:20131104
摘要:Gastric bypass surgery is associated with a major weight loss and often causes
remission in patients with type 2 diabetes. Surgery is also associated with
dramatic increases in the secretion of the gut hormones, glucagon-like peptide-1
(GLP-1) and peptide YY (PYY), both of which regulate appetite and food intake,
while GLP-1 in addition functions as an incretin hormone, stimulating insulin
secretion. It has been possible to probe the role of GLP-1 for the diabetes
resolution after gastric bypass using a GLP-1 receptor antagonist, and it is
clear that the enhanced beta cell sensitivity to glucose which underlies the
enhanced insulin secretion in the patients after the operation depends critically
on the increased GLP-1 secretion. Both hormones seem to contribute importantly to
the reduction in food intake after bypass and, therefore, to the weight loss.
Currently, there are no data to indicate that decreased secretion of the hormones
is involved in the pathogenesis of obesity and/or diabetes, but impaired
secretion generally observed in obesity (and hence also in diabetes) may
contribute to the development. Because of these effects receptor agonists for
both hormones are currently being developed for the treatment of obesity and
diabetes.

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