详细记录  
题名:Intracellular and extracellular ATP in regulation of insulin secretion from pancreatic beta cells.
作者:WANG C; GENG B; CUI Q; GUAN Y; YANG J;
来源:J Diabetes. 2013 Oct 17. doi: 10.1111/1753-0407.12098. [ IF= 0.00 ] ]
URL :10.1111/1753-0407.12098
日期:20131104
摘要:ATP synthesis and release in mitochondria play critical roles in regulating
insulin secretion in pancreatic beta cells. Mitochondrial dysfunction is mainly
characterized by a decrease in ATP production, which is a central event in the
progression of pancreatic beta cell dysfunction and diabetes. ATP has been
demonstrated to regulate insulin secretion via several pathways: 1) Intracellular
ATP directly closes ATP-sensitive potassium channel to open L-type calcium
channel, leading to an increase in free cytosolic calcium levels and exocytosis
of insulin granules; 2) A decrease in ATP production is always associated with an
increase in production of reactive oxygen species, which exerts deleterious
effects on pancreatic beta cell survival and insulin secretion. 3) ATP can be
co-secreted with insulin from pancreatic beta cells, and the released ATP
functions as an autocrine signal to modulate insulin secretory process via P2
receptors on the cell membrane. In this review, the recent findings regarding the
role and mechanism of ATP synthesis and release in regulation of insulin
secretion from pancreatic beta cells will be summarized and discussed.

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]