详细记录  
题名:Dehydroepiandrosterone-sulfate (DHEAS) promotes MIN6 cells insulin secretion via inhibition of AMP-activated protein kinase.
作者:YUE J; WANG L; HUANG R; LI S; MA J; TENG X; LIU W;
来源:Biochem Biophys Res Commun. 2013 Oct 8. pii: S0006-291X(13)01656-2. doi: [ IF= 0.00 ] ]
URL :10.1016/j.bbrc.2013.10.002
日期:20131104
摘要:Derived from adrenal cortical, dehydroepiandrosterone-sulfate (DHEAS) is a
precursor to androgens and estrogens, with various bioactivities. Although it has
the property of anti-diabetes, the long-term effect of DHEAS on insulin secretion
in beta-cells is still unclear. In this study, the effect of DHEAS on the insulin
secretion activity in MIN6 cell lines in vitro was assessed. Insulin biosynthesis
and secretion were stimulated by DHEAS for 24h. DHEAS inhibited the AMPK
activation and upregulated the expression of ACC-1. These findings indicate that
DHEAS may exert prominent stimulatory effects on insulin secretion partly via
AMPK inhibition and ACC-1 upregulation.

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