详细记录  
题名:Glucose-stimulated insulin secretion: the hierarchy of its multiple cellular and subcellular mechanisms.
作者:MEDA P; SCHUIT F;
来源:Diabetologia. 2013 Oct 11. [ IF= 6.49 ] ]
URL :10.1007/s00125-013-3073-z
日期:20131104
摘要:Glucose-stimulated insulin secretion is ensured by multiple molecular, cellular
and tissue events. In this issue of Diabetologia, Low et al (DOI:
10.1007/s00125-013-3019-5 ) have taken an important new step towards
understanding the hierarchical organisation of these events, by monitoring in
vitro the individual exocytosis of multiple beta cells within intact mouse
islets. The authors show that glucose stimulation markedly increases the number
of exocytotic events per cell and, to a lesser extent, the number of beta cells
contributing to this event. In this commentary we discuss these novel
observations and propose that metabolic and electrical coupling of islet beta
cells is responsible for a more homogeneous glucose-induced secretory response of
cells in an intact islet as compared with isolated beta cells.

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