详细记录  
题名:Minireview: intraislet regulation of insulin secretion in humans.
作者:RUTTER GA; HODSON DJ;
来源:Mol Endocrinol. 2013 Dec;27(12):1984-95. doi: 10.1210/me.2013-1278. Epub 2013 Nov [ IF= 0.00 ] ]
URL :10.1210/me.2013-1278
日期:20140102
摘要:The higher organization of beta-cells into spheroid structures termed islets of
Langerhans is critical for the proper regulation of insulin secretion. Thus,
rodent beta-cells form a functional syncytium that integrates and propagates
information encoded by secretagogues, producing a "gain-of-function" in hormone
release through the generation of coordinated cell-cell activity. By contrast,
human islets possess divergent topology, and this may have repercussions for the
cell-cell communication pathways that mediate the population dynamics underlying
the intraislet regulation of insulin secretion. This is pertinent for type 2
diabetes mellitus pathogenesis, and its study in rodent models, because
environmental and genetic factors may converge on these processes in a
species-specific manner to precipitate the defective insulin secretion associated
with glucose intolerance. The aim of the present minireview is therefore to
discuss the structural and functional underpinnings that influence insulin
secretion from human islets, and the possibility that dyscoordination between
individual beta-cells may play an important role in some forms of type 2 diabetes
mellitus.

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