详细记录  
题名:Glucose regulation of glucagon secretion.
作者:GYLFE E; GILON P;
来源:Diabetes Res Clin Pract. 2014 Jan;103(1):1-10. doi: [ IF= 0.00 ] ]
URL :10.1016/j.diabres.2013.11.019
日期:20140217
摘要:Glucagon secreted by pancreatic alpha-cells is the major hyperglycemic hormone
correcting acute hypoglycaemia (glucose counterregulation). In diabetes the
glucagon response to hypoglycaemia becomes compromised and chronic
hyperglucagonemia appears. There is increasing awareness that glucagon excess may
underlie important manifestations of diabetes. However opinions differ widely how
glucose controls glucagon secretion. The autonomous nervous system plays an
important role in the glucagon response to hypoglycaemia. But it is clear that
glucose controls glucagon secretion also by mechanisms involving direct effects
on alpha-cells or indirect effects via paracrine factors released from
non-alpha-cells within the pancreatic islets. The present review discusses these
mechanisms and argues that different regulatory processes are involved in a
glucose concentration-dependent manner. Direct glucose effects on the alpha-cell
and autocrine mechanisms are probably most significant for the glucagon response
to hypoglycaemia. During hyperglycaemia, when secretion from beta- and
delta-cells is stimulated, paracrine inhibitory factors generate pulsatile
glucagon release in opposite phase to pulsatile release of insulin and
somatostatin. High concentrations of glucose have also stimulatory effects on
glucagon secretion that tend to balance and even exceed the inhibitory influence.
The latter actions might underlie the paradoxical hyperglucagonemia that
aggravates hyperglycaemia in persons with diabetes.

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