详细记录  
题名:The PARK2 gene is involved in the maintenance of pancreatic beta-cell functions related to insulin production and secretion.
作者:JIN HS; KIM J; LEE SJ; KIM K; GO MJ; LEE JY; LEE HJ; SONG J; JEON BT; ROH GS; KIM SJ; KIM BY; HONG KW; YOO YH; OH B; KANG Y; JEONG SY;
来源:Mol Cell Endocrinol. 2014 Jan 25;382(1):178-89. doi: 10.1016/j.mce.2013.09.031. [ IF= 0.00 ] ]
URL :10.1016/j.mce.2013.09.031
日期:20140217
摘要:Several association studies have implicated the PARK2 gene that encodes
parkin--the key molecule orchestrating the mitochondrial quality control
system--as a candidate susceptibility gene for diabetes. A total of 7551
unrelated Korean KARE cohort subjects were analyzed to investigate the
association between the PARK2 single nucleotide polymorphism (SNP) and
quantitative glycemic traits. Two SNPs, rs10455889 and rs9365294, were
significantly associated with fasting plasma glucose level (p= approximately
1.2x10(-4)) and insulin secretion indices (p= approximately 7.4x10(-5)) in male
KARE subjects. Parkin was expressed predominantly in the rat pancreatic islets.
Downregulation of the Park2 gene in rat INS-1 beta-cells resulted in a
significant decrease in the glucose-stimulated insulin secretion, intracellular
insulin gene expression, and intracellular ATP level. The Park2-depleted
beta-cells also exhibited increased mitochondrial fragmentation and ROS
production and decreased mitochondrial membrane potential. Both population-based
statistical evaluation and experimental evidence demonstrated a fundamental role
of the PARK2 gene in the maintenance of beta-cell function.

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