详细记录  
题名:Secreted frizzled-related protein 4 (SFRP4) and fractalkine (CX3CL1) - Potential new biomarkers for beta-cell dysfunction and diabetes.
作者:BERGMANN K; SYPNIEWSKA G;
来源:Clin Biochem. 2014 Mar 24. pii: S0009-9120(14)00120-9. doi: [ IF= 0.00 ] ]
URL :10.1016/j.clinbiochem.2014.03.007
日期:20140408
摘要:The discovery of new risk factors for diabetes is a major challenge for
contemporary science. Pathogenesis of type 2 diabetes mellitus (T2DM) is closely
related to adipose tissue dysfunction. The aim of this review was to describe
recently discovered cytokines: fractalkine (CX3CL1, FKN) and secreted
frizzled-related protein 4 (SFRP4) as potential biomarkers of early beta cell
dysfunction and diabetes. The association of CX3CL1 and SFRP4 with low-grade
inflammation in adipose tissue links obesity with disturbances in insulin
secretion and impaired glucose metabolism, therefore it indicates new therapeutic
and preventive targets in both healthy and diabetic subjects.

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