详细记录  
题名:Nutrient regulation of insulin secretion and action.
作者:NEWSHOLME P; CRUZAT V; ARFUSO F; KEANE KN;
来源:J Endocrinol. 2014 Mar 25. [ IF= 0.00 ] ]
URL :10.1530/JOE-13-0616
日期:20140408
摘要:Pancreatic beta-cell function is of critical importance in the regulation of fuel
homeostasis, and metabolic dysregulation is a hallmark of diabetes mellitus (DM).
The beta-cell is an intricately designed cell type that couples metabolism of
dietary sources of carbohydrates, amino acids, and lipids to insulin secretory
mechanisms, such that insulin release occurs at appropriate times to ensure
efficient nutrient uptake and storage by target tissues. However, chronic
exposure to high nutrient concentrations results in altered metabolism that
impacts negatively on insulin exocytosis, insulin action, and may ultimately lead
to development of DM. Reduced action of insulin in target tissues is associated
with impairment of insulin signalling and contributes to insulin resistance (IR),
a condition often associated with obesity, and a major risk factor for DM. The
altered metabolism of nutrients by insulin sensitive target tissues (muscle,
adipose, and liver) can result in high circulating levels of glucose and various
lipids, which further impact on pancreatic beta-cell function, IR, and
progression of the metabolic syndrome. Here, we have considered the role played
by the major nutrient groups, carbohydrates, amino acids, and lipids, in
mediating beta-cell insulin secretion, while also exploring the interplay between
amino acids and insulin action in muscle. We also focus on the effects of altered
lipid metabolism in adipose and liver resulting from activation of inflammatory
processes commonly observed in DM pathophysiology. The aim of this review is to
describe commonalities and differences in metabolism related to insulin secretion
and action, pertinent to the development of DM.

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]