详细记录  
题名:Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and Type 2 diabetes: Action LADA 8.
作者:JUHL CB; BRADLEY U; HOLST JJ; LESLIE RD; YDERSTRAEDE KB; HUNTER S;
来源:Diabet Med. 2014 Mar 15. doi: 10.1111/dme.12434. [ IF= 0.00 ] ]
URL :10.1111/dme.12434
日期:20140408
摘要:AIMS: To explore insulin sensitivity and insulin secretion in people with latent
autoimmune diabetes in adulthood (LADA) compared with that in people with Type 2
diabetes. METHODS: A total of 12 people with LADA, defined as glutamic acid
decarboxylase (GAD) antibody positivity and > 1 year of insulin independency
(group A) were age-matched pairwise to people with Type 2 diabetes (group B) and
to six people with Type 2 diabetes of similar age and BMI (group C). beta-cell
function (first-phase insulin secretion and assessment of insulin pulsatility),
insulin sensitivity (hyperinsulinemic-euglycemic clamp) and metabolic response
during a mixed meal were studied. RESULTS: Both first-phase insulin secretion and
insulin release during the meal were greater (P=0.05 and P=0.009, respectively)
in Type 2 diabetes as compared with LADA; these differences were lost on
adjustment for BMI (group C) and could be explained by BMI alone in a
multivariate analysis. Neither insulin pulsatility, incretin secretion nor
insulin sensitivity differed among the groups. CONCLUSIONS: We found no evidence
that LADA and Type 2 diabetes were distinct disease entities beyond the
differences explained by BMI. This article is protected by copyright. All rights
reserved.

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