详细记录  
题名:Restoring Insulin Secretion (RISE): Design of Studies of beta-Cell Preservation in Prediabetes and Early Type 2 Diabetes Across the Life Span.

来源:Diabetes Care. 2014 Mar;37(3):780-8. doi: 10.2337/dc13-1879. Epub 2013 Nov 5. [ IF= 7.74 ] ]
URL :10.2337/dc13-1879
日期:20140408
摘要:OBJECTIVE The Restoring Insulin Secretion (RISE) Consortium is testing
interventions designed to preserve or improve beta-cell function in prediabetes
or early type 2 diabetes. RESEARCH DESIGN AND METHODS beta-Cell function is
measured using hyperglycemic clamps and oral glucose tolerance tests (OGTTs). The
adult medication protocol randomizes participants to 12 months of placebo,
metformin alone, liraglutide plus metformin, or insulin (3 months) followed by
metformin (9 months). The pediatric medication protocol randomizes participants
to metformin or insulin followed by metformin. The adult surgical protocol
randomizes participants to gastric banding or metformin (24 months). Adult
medication protocol inclusion criteria include fasting plasma glucose 95-125
mg/dL (5.3-6.9 mmol/L), OGTT 2-h glucose >/=140 mg/dL (>/=7.8 mmol/L), HbA1c
5.8-7.0% (40-53 mmol/mol), and BMI 25-40 kg/m(2). Adult surgical protocol
criteria are similar, except for fasting plasma glucose >/=90 mg/dL (>/=5.0
mmol/L), BMI 30-40 kg/m(2), HbA1c <7.0% (<53 mmol/mol), and diabetes duration <12
months. Pediatric inclusion criteria include fasting plasma glucose >/=90 mg/dL
(>/=5.0 mmol/L), 2-h glucose >/=140 mg/dL (>/=7.8 mmol/L), HbA1c mmol/mol), BMI >85th percentile and diabetes <6 months. RESULTS Primary outcomes are clamp-derived glucose-stimulated
C-peptide secretion and maximal C-peptide response to arginine during
hyperglycemia. Measurements are made at baseline, after 12 months on treatment,
and 3 months after treatment withdrawal (medication protocols) or 24 months
postintervention (surgery protocol). OGTT-derived measures are also obtained at
these time points. CONCLUSIONS RISE is determining whether medication or surgical
intervention strategies can mitigate progressive beta-cell dysfunction in adults
and youth with prediabetes or early type 2 diabetes.

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]