详细记录  
题名:Intracellular and extracellular adenosine triphosphate in regulation of insulin secretion from pancreatic beta cells (beta).
作者:WANG C; GENG B; CUI Q; GUAN Y; YANG J;
来源:J Diabetes. 2014 Mar;6(2):113-9. doi: 10.1111/1753-0407.12098. Epub 2013 Nov 20. [ IF= 0.00 ] ]
URL :10.1111/1753-0407.12098
日期:20140408
摘要:Adenosine triphosphate (ATP) synthesis and release in mitochondria play critical
roles in regulating insulin secretion in pancreatic beta cells. Mitochondrial
dysfunction is mainly characterized by a decrease in ATP production, which is a
central event in the progression of pancreatic beta cell dysfunction and
diabetes. ATP has been demonstrated to regulate insulin secretion via several
pathways: (i) Intracellular ATP directly closes ATP-sensitive potassium channel
to open L-type calcium channel, leading to an increase in free cytosolic calcium
levels and exocytosis of insulin granules; (ii) A decrease in ATP production is
always associated with an increase in production of reactive oxygen species,
which exerts deleterious effects on pancreatic beta cell survival and insulin
secretion; and (iii) ATP can be co-secreted with insulin from pancreatic beta
cells, and the released ATP functions as an autocrine signal to modulate insulin
secretory process via P2 receptors on the cell membrane. In this review, the
recent findings regarding the role and mechanism of ATP synthesis and release in
regulation of insulin secretion from pancreatic beta cells will be summarized and
discussed.

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