详细记录  
题名:The Resist Diabetes trial: Rationale, design, and methods of a hybrid efficacy/effectiveness intervention trial for resistance training maintenance to improve glucose homeostasis in older prediabetic adults.
作者:MARINIK EL; KELLEHER S; SAVLA JT; WINETT RA; DAVY BM;
来源:Contemp Clin Trials. 2013 Nov 16. pii: S1551-7144(13)00177-8. doi: [ IF= 0.00 ] ]
URL :10.1016/j.cct.2013.11.006
日期:20131203
摘要:Advancing age is associated with reduced levels of physical activity, increased
body weight and fat, decreased lean body mass, and a high prevalence of type 2
diabetes (T2D). Resistance training (RT) increases muscle strength and lean body
mass, and reduces risk of T2D among older adults. The Resist Diabetes trial will
determine if a social cognitive theory (SCT)-based intervention improves RT
maintenance in older, prediabetic adults, using a hybrid efficacy/effectiveness
approach. Sedentary, overweight/obese (BMI: 25-39.9kg/m2) adults aged 50-69
(N=170) with prediabetes (impaired fasting glucose and/or impaired glucose
tolerance) completed a supervised 3-month RT (2x/wk) initiation phase and were
then randomly assigned (N=159; 94% retention) to one of two 6-month maintenance
conditions: SCT or standard care. The SCT intervention consisted of faded
contacts compared to standard care. Participants continue RT at an approved,
self-selected community facility during maintenance. A subsequent 6-month period
involves no contact for both conditions. Assessments occur at baseline and months
3 (post-initiation), 9 (post-intervention), and 15 (six months after no contact).
Primary outcomes are prediabetes indices (i.e., impaired fasting and 2-hour
glucose concentration) and strength. Secondary measures include insulin
sensitivity, beta-cell responsiveness, and disposition index (oral glucose and
C-peptide minimal model); adherence; body composition; and SCT measures. Resist
Diabetes is the first trial to examine the effectiveness of a high fidelity
SCT-based intervention for maintaining RT in older adults with prediabetes to
improve glucose homeostasis. Successful application of SCT constructs for RT
maintenance may support translation of our RT program for diabetes prevention
into community settings.

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