详细记录  
题名:Growth hormone prevents the development of autoimmune diabetes.
作者:VILLARES R; KAKABADSE D; JUARRANZ Y; GOMARIZ RP; MARTINEZ-A C; MELLADO M;
来源:Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4619-27. doi: [ IF= 0.00 ] ]
URL :10.1073/pnas.1314985110
日期:20131203
摘要:Evidence supports a relationship between the neuroendocrine and the immune
systems. Data from mice that overexpress or are deficient in growth hormone (GH)
indicate that GH stimulates T and B-cell proliferation and Ig synthesis, and
enhances maturation of myeloid progenitor cells. The effect of GH on autoimmune
pathologies has nonetheless been little studied. Using a murine model of type 1
diabetes, a T-cell-mediated autoimmune disease characterized by immune cell
infiltration of pancreatic islets and destruction of insulin-producing
beta-cells, we observed that sustained GH expression reduced prodromal disease
symptoms and eliminated progression to overt diabetes. The effect involves
several GH-mediated mechanisms; GH altered the cytokine environment, triggered
anti-inflammatory macrophage (M2) polarization, maintained activity of the
suppressor T-cell population, and limited Th17 cell plasticity. In addition, GH
reduced apoptosis and/or increased the proliferative rate of beta-cells. These
results support a role for GH in immune response regulation and identify a unique
target for therapeutic intervention in type 1 diabetes.

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