题名：Efficient beta-Cell Regeneration by a Combination of Neogenesis and Replication Following beta-Cell Ablation and Reversal of Pancreatic Duct Ligation.
作者：HAO E; LEE SH; LEVINE F;
来源：Stem Cells. 2013 Nov;31(11):2388-95. doi: 10.1002/stem.1492. [ IF= 0.00 ] ]
摘要：Achieving efficient beta-cell regeneration is a major goal of diabetes research.
Previously, we found that a combination of beta-cell ablation and pancreatic duct
ligation led to beta-cell regeneration by direct conversion from alpha-cells.
Here, we studied the effect of surgical reversal of the duct ligation, finding
that there was a wave of beta-cell replication following reversal. The
combination of beta-cell neogenesis prior to reversal of the duct ligation and
beta-cell replication following reversal resulted in efficient beta-cell
regeneration and eventual recovery of function. This provides an important proof
of principle that efficient beta-cell regeneration is possible, even from a
starting point of profound beta-cell ablation. This has important implications
for efforts to promote beta-cell regeneration. Stem Cells 2013;31:2388-2395.
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