详细记录  
题名:The Role of SOX9 Transcription Factor in Pancreatic and Duodenal Development.
作者:BELO J; KRISHNAMURTHY M; OAKIE A; WANG R;
来源:Stem Cells Dev. 2013 Nov 15;22(22):2935-43. doi: 10.1089/scd.2013.0106. Epub 2013 [ IF= 0.00 ] ]
URL :10.1089/scd.2013.0106
日期:20131203
摘要:Progenitor expansion during development is a highly regulated process dictating
the final organ size, while expansion of specific progenitor populators can
adjust the final cellular composition of the organ. Understanding factors
involved in these pathways is required to develop cell-based therapies such as
beta-cell transplantation for conditions such as diabetes mellitus. One versatile
factor controlling both processes as well as a network of other proteins involved
in pancreatic and duodenal development is the transcription factor SOX9. This
review will focus on a comparison of SOX9 function during progenitor expansion
and differentiation in the developing pancreas and duodenum with specific focus
on endocrine development. During human pancreatic development, SOX9 functions in
a dose-dependent manner to regulate epithelial progenitor expansion and endocrine
differentiation. SOX9 expression is eventually limited to a subset of ductal and
centroacinar cells, hypothesized to be the pancreatic stem cell compartment.
Similarly, during duodenal development, SOX9 is expressed in most early
epithelial progenitors and becomes gradually restricted to proliferative
progenitors in the lower crypts, as well as mature Paneth and enteroendocrine
cells indicating some differences in functional roles. However, in both
developmental contexts, SOX9 is involved in pathways responsible for cellular
proliferation and differentiation, such as Notch and Wnt. With its adaptable and
central function in progenitor control, SOX9 represents an attractive target for
manipulation for in vitro progenitor expansion and differentiation meriting
further investigation.

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