详细记录  
题名:Red blood cells and hemoglobin in hypoxic pulmonary vasoconstriction.
作者:Deem S. Related
来源:Adv Exp Med Biol. 2006;588:217-31. Review.
URL :http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17089892&query_hl=9&itool=pubmed_docsum
日期:070130
摘要:Department of Anesthesiology, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA.sdeem@u.washington.edu


Abstract

Nitric oxide (NO) plays an important role in the modulation of hypoxic pulmonary vasoconstriction; in turn, red blood cells (RBCs) augment HPV by hemoglobin-mediated oxidation and inactivation of NO. In addition, scavenging of reactive oxygen species by RBCs may play a role in augmentation of HPV. NO delivery and/or production by RBCs does not appear to be important in the control of pulmonary vasomotor tone. This review will discuss regulation of HPV by RBCs with an emphasis on hemoglobin-NO interactions. In addition, the review will discuss how biologic (S-nitrosation) or pharmacologic (cross-linking) modification of hemoglobin may affect pulmonary circulatory-hemoglobin interactions.

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