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题名:A hypothesis for an embryonic origin of pluripotent Oct-4+ stem cells in adult bone marrow and other tissues
作者:M Z Ratajczak, B Machalinski, W Wojakowski, J Ratajczak, M Kucia
来源:Leukemia[IF=6.612], (08 Mar 2007) Reviews
URL :http://dx.doi.org/10.1038/sj.leu.2404630
日期:070330
摘要: M Z Ratajczak1, B Machalinski2, W Wojakowski3, J Ratajczak1 and M Kucia1

1Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
2Department of Physiology, Pomeranian Medical University, Szczecin, Poland
3Third Department of Cardiology, Medical University of Silesia, Katowice, Poland

Correspondence: Dr MZ Ratajczak, Hoenig Endowed Chair in Cancer Biology, Professor and Director of Stem Cell Biology Program, University of Louisville, 580 S. Preston St, Baxter II, Rm. 119E, Louisville, KY 40202, Kentucky, USA. E-mail: mzrata01@louisville.edu

Received 13 January 2007; Revised 29 January 2007; Accepted 31 January 2007; Published online 8 March 2007.

Abstract

Accumulating evidence demonstrates that adult tissues contain a population of stem cells that express early developmental markers such as stage-specific embryonic antigen and transcription factors Oct-4 and Nanog. These are the markers characteristic for embryonic stem cells, epiblast stem cells and primordial germ cells. The presence of these stem cells in adult tissues including bone marrow, epidermis, bronchial epithelium, myocardium, pancreas and testes supports the concept that adult tissues contain some population of pluripotent stem cells that is deposited in embryogenesis during early gastrulation. In this review we will discuss these data and present a hypothesis that these cells could be direct descendants of the germ lineage. The germ lineage in order to pass genes on to the next generations creates soma and thus becomes a mother lineage for all somatic cell lineages present in the adult body.

Keywords: Oct-4, Nanog, SSEA-4, VSELs, embryonic stem cells 38.

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