详细记录  
题名:Daughter leaves mother
作者:Sinad Hayes
来源:Nature Cell Biology[IF=19.717], 9, 253 - 253 (01 Mar 2007) News and Views
URL :http://dx.doi.org/10.1038/ncb0307-253
日期:070330
摘要: Article

The mother centrosome (labelled by embryonic expression of GFPCPACT) remains close to the hub-GSC interface, whereas the non-labelled daughter centrosome migrates toward the opposite side of the GSC. Green, GFPCPACT; Red, FasIII (hub) and -tubulin (centrosome); blue, Vasa (germ cells). The centrosomes are indicated by white arrows. The scale bar represents 10m.

A defining characteristic of stem cells is their ability to divide asymmetrically into a self renewed mother cell and a differentiating daughter cell. Yamashita et al. (Science 315, 518C521; 2007) have recently shown that in the Drosophila male germ line differential centrosome inheritance regulates this process.

Drosophila male germline stem cells (GSCs) are induced to self renew by signals from the stem cell niche composed of proximal somatic hub cells in the testes. Asymmetric GSCs division is governed by spindle orientation perpendicular to the hub cells, to produce a stem cell attached to the niche and a differentiating gonialblast. The positioning of centrosomes during interphase orientates the spindle: in G1, the single centrosome is located adjacent to the hub, and in G2 the duplicated centrosomes separate before spindle formation, so that one remains next to the hub and the other migrates to the opposite side of the cell. 66.

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