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题名:The Mother of All Stem Cells?
作者:Allan C. Spradling and Yixian Zheng
来源:Science[IF=30.927]. 26 January 2007: Vol. 315. no. 5811, pp. 469 - 470, Perspectives
URL :http://dx.doi.org/10.1126/science.1138237
日期:070330
摘要: Allan C. Spradling and Yixian Zheng

The authors are in the Department of Embryology and Howard Hughes Medical Institute, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA. E-mail: spradling@ciwemb.edu

Abstract

Partitioning of centrosomes during division of Drosophila germline stem cells may help keep one daughter as a stem cell and move the other toward differentiation.

Article

The stem cells that sustain metazoan tissues face a difficult challenge. Each time a stem cell divides--it can divide indefinitely--it risks damage from errors in the duplication and segregation of genetic and cellular material that could stunt its vitality or propel it toward a cancerous state. Normally, each division must be asymmetric to ensure that only one daughter cell differentiates, while the other becomes a stem cell, thus renewing the stem cell population. Yet stem cells safely grow and divide many more times than other cell types, including their own daughters. On page 518 of this issue, Yamashita et al. (1) examine the role of one of the most fundamental cellular components in supporting stem cell function--the centrosome. Centrosomes organize the microtubule-rich mitotic spindle that directs how chromosomes and other materials are distributed between daughter cells at cell division (mitosis). The authors show that male germline stem cells in the fruit fly Drosophila melanogaster differentially position their mother and daughter centrosomes during mitosis. As part of this strategy, which ensures asymmetric division, the stem cell permanently retains the mother centrosome across many cell divisions, raising the possibility that differential centrosomal inheritance is essential to stem cell biology.... 5

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